Results 1 to 10 of about 27,055 (211)

In vivo mutagenicity assessment of styrene in MutaMouse liver and lung. [PDF]

Genes Environ, 2023
Abstract Background Styrene (CAS 100-42-5) is widely used as polystyrene and acrylonitrile–butadiene–styrene resin such as plastic, rubber, and paint. One of the primary uses of styrene is food utensils and containers, but a small amount of styrene transferred into food can be ingested by eating.
Murata Y, Natsume M, Iso T, Shigeta Y, Hirose N, Umano T, Horibata K, Sugiyama KI, Masumura K, Hirose A, Matsumoto M.   +10 more
europepmc   +4 more sources

Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints. [PDF]

Environ Mol Mutagen
ABSTRACTThe benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making. There is considerable controversy regarding the most appropriate benchmark response (BMR) for genotoxicity endpoints.
White PA, Chen G, Chepelev N, Bell MA, Gallant LR, Johnson GE, Zeller A, Beal MA, Long AS.   +8 more
europepmc   +5 more sources

In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde [PDF]

Genes and Environment, 2021
Abstract Background Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA reactive. Indeed, several reports have indicated that perillaldehyde and cinnamaldehyde show
Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura   +5 more
openaire   +3 more sources

In Vitro versus In Vivo Metabolic Activation of Mutagens [PDF]

Environmental Health Perspectives, 1973
Mutagenicity testing is beginning to find a place as a factor in evaluation of the safety of compounds to which the human population is exposed. The mutation systems selected for such tests should ideally involve in vivo studies with mammals and encompass scoring of a broad spectrum of mutational events including both transmissible chromosome ...
H V, Malling, C N, Frantz
openaire   +2 more sources

In Vitro Mutagenic and Genotoxic Assessment of a Mixture of the Cyanotoxins Microcystin-LR and Cylindrospermopsin [PDF]

, 2019
The co-occurrence of various cyanobacterial toxins can potentially induce toxic effects different than those observed for single cyanotoxins, as interaction phenomena cannot be discarded. Moreover, mixtures are a more probable exposure scenario. However,
Cameán Fernández, Ana María, Díez-Quijada Jiménez, Leticia, Jos Gallego, Ángeles Mencía, Prieto Ortega, Ana Isabel, Puerto Rodríguez, María   +4 more
core   +1 more source

Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]

, 2017
Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena, Barile, Fabio, Bozovic, Mijat, DI GIACOMO, Silvia, DI SOTTO, Antonella, Izzo, Angelo A, Mazzanti, Gabriela, Parisi, Olga A, Ragno, Rino, Vitalone, Annabella   +9 more
core   +1 more source

A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly [PDF]

, 2013
Zinc-finger nucleases (ZFNs) and TAL effector nucleases (TALENs) have been shown to induce targeted mutations, but they have not been extensively tested in any animal model. Here, we describe a large-scale comparison of ZFN and TALEN mutagenicity in
Antoshechkin, Igor, Chen, Shijia, Chiu, Cindy N., Lee, Daniel A., Liu, Justin, Niles, Brett J., Oikonomou, Grigorios, Prober, David A.   +7 more
core   +1 more source

Evaluation of the genotoxic and teratogenic potential of a municipal sludge and sludge-amended soil using the amphibian Xenopus laevis and the tobacco: Nicotiana tabacum L. var. xanthi Dulieu [PDF]

, 2003
The toxic, genotoxic and teratogenicpotential of amunicipal sewage sludge was assessed using the micronucleus assay on the larvae of the amphibianXenopuslaevis and with the tobacco somatic mutation test using the yellow–green xanthiDulieu mutant a1+/a1 ...
Chenon, Pascale, Delpoux, Marcel, Gauthier, Laury, Loubières, Pascale, Séverac, Alain   +4 more
core   +4 more sources

Giemsa versus acridine orange staining in the fish micronucleus assay and validation for use in water quality monitoring [PDF]

, 2011
This study concerns a comparative analysis of the acridineorange and Giemsastaining procedures for the fish erythrocyte micronucleusassay. The goal was to optimize the assay in the context of field watermonitoring. Fish (Carassius carassius) were exposed
Gauthier, Laury, Jean, Séverine, Laplanche, Christophe, Merlina, Georges, Pinelli, Eric, Polard, Thierry   +5 more
core   +2 more sources

Mutagenic impact on fish of runoff events in agricultural areas in south-west France [PDF]

, 2011
When heavy rainfall follows herbicide application, the intense surface runoff causes stream water contamination. Aquatic organisms are then briefly exposed to a complex mixture of contaminants.
Gauthier, Laury, Jean, Séverine, Laplanche, Christophe, Merlina, Georges, Pinelli, Eric, Polard, Thierry, Sanchez-Pérez, José Miguel   +6 more
core   +2 more sources