Results 31 to 40 of about 117,900,808 (282)

The in vivo and in vitro genotoxicity of aromatic amines in relationship to the genotoxicity of benzidine [PDF]

open access: yes, 1992
Benzidine and 12 related aromatic amines have been studied for the effects of substituent groups and [pi] orbital conjugation on their genotoxicity as measured by their mutagenicity in vitro with Salmonella and by chromosomal aberrations (CA) in vivo in ...
You, Zhengqing   +4 more
core   +1 more source

An investigation into the potential mutagenicity of South African traditional medicinal plants [PDF]

open access: yes, 2010
The potential mutagenicity and clastogenicity (ability to cause chromosomal damage) of five South African traditional medicinal plants: Acokanthera oppositifolia (Lam.); Pelargonium sp. cf.
Nair, Amatheni
core   +1 more source

Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment. [PDF]

open access: yesRegul Toxicol Pharmacol
Error-corrected sequencing (ECS) is a transformative method for in vivo mutagenicity assessment, enabling direct, highly sensitive measurement of mutation frequency and spectrum.
Yauk CL   +16 more
europepmc   +3 more sources

In vivo and in vitro evaluation of betanine mutagenicity.

open access: yesCYTOLOGIA, 1990
Information about the mutagenic effect of natural food colors gives scientific support to their use as food additives. Two different forms of beet root colours were tested: form I without nitrate residues and form II with nitrate residues. Mutagenic effects were tested in vitro using the human peripheral blood lymphocyte system and in vivo using the ...
2-Froes, Nivea   +2 more
openaire   +3 more sources

Evaluation of mutagenicity of zinc oxide nanoparticles by Pig-a mutation assay in vivo

open access: yesShanghai yufang yixue, 2022
ObjectiveThe genotoxicity of zinc oxide nanoparticles (ZnO NPs) in rats was determined by Pig⁃a mutation assay in vivo.MethodsCombined with 28-day oral toxicity test, male SD rats were given ZnO NPs by oral administration for 28 days, at doses of 0, 14 ...
CHENG Xueqing   +4 more
doaj   +1 more source

Remote control of glucose homeostasis in vivo using photopharmacology

open access: yesScientific Reports, 2017
Photopharmacology describes the use of light to precisely deliver drug activity in space and time. Such approaches promise to improve drug specificity by reducing off-target effects.
Zenobia B. Mehta   +9 more
doaj   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

open access: yesAngewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao   +8 more
wiley   +2 more sources

Antimutagenic effect of curcumin and its effect on the immune response in mice

open access: yesCzech Journal of Food Sciences, 2006
A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities.
Petr Šmerák   +7 more
doaj   +1 more source

Mutagenicity studies with N-acetyl-L-aspartic acid

open access: yes, 2009
Analytical studies have reported that N-acetyl-L-aspartic acid (NAA) is present at low concentrations in many foods. The current studies were conducted to assess the mutagenicity of NAA using standard OECD guideline in vitro bacterial and in vivo ...
Delaney, Bryan   +9 more
core   +1 more source

Genotoxicity test of eight natural color additives in the Korean market

open access: yesGenes and Environment, 2022
Background Various natural color additives are preferred by many consumers over synthetic color additives because they are perceived to be safer. However, most do not have sufficient toxicity data for safety assurance.
Byungkyung Do, Hoonjeong Kwon
doaj   +1 more source

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