Results 1 to 10 of about 6,979,548 (245)

Differential genotoxicity of Polygoni Multiflori in rat and human: insights from Ames test and S9 metabolic activation system [PDF]

Scientific Reports
The Ames test is used worldwide to initially screen the mutagenic potential of new chemicals. In the standard Ames test, S. typhimurium strains (TA100, TA98, TA1535, and TA1537) and Escherichia coli (WP2uvrA) are treated with substances with/without ...
Su-Min Bak, Seng-Min Back, Da Yeon Kim, Soyoung Jung, Na-Young Jeung, Nan-Young Kim, Kang-Hyun Han, Yong-Bum Kim, Byoung-Seok Lee, Jun Hong Park, Hee Jun Cho, Hee Gu Lee, Ozkan Ozden, Sang Kyum Kim, Seong-Hoon Park   +14 more
doaj   +2 more sources

Adventures with Bruce Ames and the Ames test [PDF]

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 2019

exaly   +2 more sources

Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™

Genes and Environment, 2021
Background Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity by the Ames test because of their
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, Masamitsu Honma   +9 more
doaj   +1 more source

MUTAGENICITY OF KOJIC ACID PRODUCED FROM WILD TYPE Aspergillus oryzae [PDF]

Mesopotamia Journal of Agriculture, 2023
Kojic acid (KA) is a multipurpose natural compound, commonly used in the food and cosmetics industry. It is produced by different types of molds especially by the species Aspergillus oryzae. In this study, we test the mutagenicity of local produced kojic
Tariq Ibrahim, Salah Ahmed, Younis Younis, Michael Chikindas   +3 more
doaj   +1 more source

Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS

Genes and Environment, 2021
Background Conflicting results between bacterial mutagenicity tests (the Ames test) and mammalian carcinogenicity tests might be due to species differences in metabolism, genome structure, and DNA repair systems. Mutagenicity assays using human cells are
Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, Emiko Okada, Saori Fujishima, Mika Yamamoto, Naoko Otani, Maki Nakamura, Ryoichi Nishimura, Maya Ueda, Masayuki Mishima, Kaori Matsuzaki, Akira Takeiri, Kenji Tanaka, Yuki Okada, Munehiro Nakagawa, Shuichi Hamada, Akihiko Kajikawa, Hiroshi Honda, Jun Adachi, Kentaro Misaki, Kumiko Ogawa, Masamitsu Honma   +29 more
doaj   +1 more source

White phosphorus genotoxicity

BIO Web of Conferences, 2021
The genotoxicity of white phosphorus was previously evaluated using the Ames test, which demonstrated the absence of toxicity. However, with all the advantages of this method, the use of the Ames test has some shortfallsin assessing genotoxicity.
Mindubaev Anton, Babynin Edward, Minzanova Salima, Badeeva Elena, Akosah Yaw   +4 more
doaj   +1 more source

Mutagenicity of Chinese traditional medicine Semen Armeniacae amarum by two modified Ames tests

BMC Complementary and Alternative Medicine, 2009
Background Semen armeniacae amarum (SAA) is a Chinese traditional medicine and has long been used to control acute lower respiratory tract infection and asthma, as a result of its expectorant and antiasthmatic activities.
Cai Yupin, Tian Xiao, Zhang Hui, Liu Bo, Jin Jianling, Gao Peiji   +5 more
doaj   +1 more source

Ultrasound-assisted Strecker synthesis of novel 2-(hetero)aryl-2-(arylamino)acetonitrile derivatives

Beilstein Journal of Organic Chemistry, 2020
This work describes an efficient, simple, and ecofriendly sonochemical procedure for the preparation of new α-(arylamino)acetonitrile derivatives C-substituted with phenothiazine or ferrocene units.
Emese Gal, Luiza Gaina, Hermina Petkes, Alexandra Pop, Castelia Cristea, Gabriel Barta, Dan Cristian Vodnar, Luminiţa Silaghi-Dumitrescu   +7 more
doaj   +1 more source

Experiences of frontline nurses with adverse medical events in a regional referral hospital in northern Ghana: a cross-sectional study

Tropical Medicine and Health, 2019
Background Adverse medical events (AMEs) are threats to delivery of quality healthcare services, particularly in resource-poor settings such as Ghana.
Robert Kaba Alhassan, Bilson Halilu, Saeed Mohammed Benin, Bentor Francis Donyor, Abubakar Yussuf Kuwaru, Dudu Yipaalanaa, Edward Nketiah-Amponsah, Martin Amogre Ayanore, Aaron Asibi Abuosi, Agani Afaya, Solomon Mohammed Salia, Japiong Milipaak   +11 more
doaj   +1 more source

Correlation analysis of heat stability of veterinary antibiotics by structural degradation, changes in antimicrobial activity and genotoxicity

Veterinární Medicína, 2011
The relationship between the structural degradation of veterinary antibiotics, their antimicrobial activity, and possible mutagenicity after heating have not been well investigated sequentially.
M.K. Hsieh, C.L. Shyu, J.W. Liao, C.A. Franje, Y. J. Huang, S.K. Chang, P.Y. Shih, C.C. Chou   +7 more
doaj   +1 more source