Direct Comparison of the Lowest Effect Concentrations of Mutagenic Reference Substances in Two Ames Test Formats [PDF]
Toxics, 2021 The Ames assay is the standard assay for identifying DNA-reactive genotoxic substances. Multiple formats are available and the correct choice of an assay protocol is essential for achieving optimal performance, including fit for purpose detection limits ...
Elisabeth Pinter +2 more
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Microbial Mutagenicity Assay: Ames Test [PDF]
Bio-Protocol, 2018 The Microbial mutagenicity Ames test is a bacterial bioassay accomplished in vitro to evaluate the mutagenicity of various environmental carcinogens and toxins. While Ames test is used to identify the revert mutations which are present in strains, it can
Urvashi Vijay +4 more
doaj +3 more sources
Antimutagenic effects of 2,6-Dimethylpyridine-N-oxide using fluctuation ames test [PDF]
Toxicology ReportsThe mutagenic potential of chemical agents is a significant concern in the field of genetic toxicology. The 2,6-Dimethylpyridine-N-oxide is believed to have antimutagenic properties, which could be beneficial for applications in pharmaceutical and ...
Olesia Vasetska +4 more
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Detection of mutations: from Ames test to duplex sequencing [PDF]
Frontiers in Molecular BiosciencesMutation is a biological phenomenon observed in all life forms from viruses to humans. This inescapable process has fascinated scientists for nearly a century.
Niketa Bhawsinghka, Roel M. Schaaper
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Evaluation of acetone as a solvent for the Ames test [PDF]
Genes and Environment, 2020 Background Acetone is a common alternative solvent used in the Ames test when test chemicals are unstable or poorly soluble in water or dimethyl sulfoxide (DMSO).
Tomomi Shibata +6 more
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Development, qualification, validation and application of the Ames test using a VITROCELL® VC10® smoke exposure system [PDF]
Toxicology Reports, 2018 The Ames test has established use in the assessment of potential mutagenicity of tobacco products but has generally been performed using partitioned exposures (e.g. total particulate matter [TPM], gas vapor phase [GVP]) rather than whole smoke (WS).
Kathy Fowler +4 more
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Investigating the Mutagenic Effects of Three Commonly Used Pulpotomy Agents Using the Ames Test [PDF]
Advanced Pharmaceutical Bulletin, 2015 Purpose: The mutagenic potency of materials used in dentistry is of great concern. The Ames test is a bacterial reverse mutation assay, which is used to determine the mutagenicity potential of chemicals.
Mohammad Samiei +6 more
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Effect of episomally encoded DNA polymerases on chemically induced mutagenesis at the hisG46 target in Ames test [PDF]
Genes and Environment, 2020 Background The standard Ames test strains owe their high sensitivity to chemical and physical mutagens to the episomal Y-family DNA polymerase RI encoded by the mucAB operon. The S. typhimurium test strains carry also another related samAB operon on a 60-
Petr Grúz +4 more
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Mutagenicity of Flavonoids Assayed by Bacterial Reverse Mutation (Ames) Test
Molecules, 2012 The mutagenicity of ten flavonoids was assayed by the Ames test, in <em>Salmonella typhimurium</em> strains TA98, TA100 and TA102, with the aim of establishing hydroxylation pattern-mutagenicity relationship profiles.
Lourdes Campaner Santos +2 more
exaly +3 more sources
Structure-mutagenicity relationships on quinoline and indole analogues in the Ames test [PDF]
Genes and EnvironmentBackground Although the in silico predictive ability of the Ames test results has recently made remarkable progress, there are still some chemical classes for which the predictive ability is not yet sufficient due to a lack of Ames test data.
Masaki Kurakami +7 more
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