Results 21 to 30 of about 353,357 (301)

Experiences of frontline nurses with adverse medical events in a regional referral hospital in northern Ghana: a cross-sectional study

Tropical Medicine and Health, 2019
Background Adverse medical events (AMEs) are threats to delivery of quality healthcare services, particularly in resource-poor settings such as Ghana.
Robert Kaba Alhassan, Bilson Halilu, Saeed Mohammed Benin, Bentor Francis Donyor, Abubakar Yussuf Kuwaru, Dudu Yipaalanaa, Edward Nketiah-Amponsah, Martin Amogre Ayanore, Aaron Asibi Abuosi, Agani Afaya, Solomon Mohammed Salia, Japiong Milipaak   +11 more
doaj   +1 more source

Bacterial mutagenicity test data: collection by the task force of the Japan pharmaceutical manufacturers association

Genes and Environment, 2021
Background Ames test is used worldwide for detecting the bacterial mutagenicity of chemicals. In silico analyses of bacterial mutagenicity have recently gained acceptance by regulatory agencies; however, current in silico models for prediction remain to ...
Atsushi Hakura, Takumi Awogi, Toshiyuki Shiragiku, Atsushi Ohigashi, Mika Yamamoto, Kayoko Kanasaki, Hiroaki Oka, Yasuaki Dewa, Shunsuke Ozawa, Kouji Sakamoto, Tatsuya Kato, Eiji Yamamura   +11 more
doaj   +1 more source

Absence of genotoxic effects of the chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one) and its potential chemoprevention against DNA damage using in vitro and in vivo assays. [PDF]

PLoS ONE, 2017
The chalcone (E)-1-(2-hydroxyphenyl)-3-(4-methylphenyl)-prop-2-en-1-one), or 2HMC, displays antileishmanial, antimalarial, and antioxidant activities. The aim of this study was to investigate the cytotoxic, genotoxic, mutagenic, and protective effects of
Débora Cristina da Silva Lima, Camila Regina do Vale, Jefferson Hollanda Véras, Aline Bernardes, Caridad Noda Pérez, Lee Chen-Chen   +5 more
doaj   +1 more source

Ultrasound-assisted Strecker synthesis of novel 2-(hetero)aryl-2-(arylamino)acetonitrile derivatives

Beilstein Journal of Organic Chemistry, 2020
This work describes an efficient, simple, and ecofriendly sonochemical procedure for the preparation of new α-(arylamino)acetonitrile derivatives C-substituted with phenothiazine or ferrocene units.
Emese Gal, Luiza Gaina, Hermina Petkes, Alexandra Pop, Castelia Cristea, Gabriel Barta, Dan Cristian Vodnar, Luminiţa Silaghi-Dumitrescu   +7 more
doaj   +1 more source

Correlation analysis of heat stability of veterinary antibiotics by structural degradation, changes in antimicrobial activity and genotoxicity

Veterinární Medicína, 2011
The relationship between the structural degradation of veterinary antibiotics, their antimicrobial activity, and possible mutagenicity after heating have not been well investigated sequentially.
M.K. Hsieh, C.L. Shyu, J.W. Liao, C.A. Franje, Y. J. Huang, S.K. Chang, P.Y. Shih, C.C. Chou   +7 more
doaj   +1 more source

Antimutagenic effect of curcumin and its effect on the immune response in mice

Czech Journal of Food Sciences, 2006
A wide array of antioxidative and anti-inflammatory substances derived from edible plants have been reported to possess chemopreventive and chemoprotective activities.
Petr Šmerák, Zdeňka Polívková, Helena Šestáková, Rudolf Štětina, Ivo Bárta, Martina Langová, Bohumil Turek, Jiřina Bártová   +7 more
doaj   +1 more source

Evaluation of Betulin Mutagenicity by Salmonella/Microsome Test [PDF]

Advanced Pharmaceutical Bulletin, 2016
Purpose: Betulin is a pentacyclic triterpene found in the outer barks of innumerous plants. This secondary metabolite is easily isolated from plants with the major interest in converting it to betulinic acid, which pharmacological properties were much ...
Edson Hideaki Yoshida, Natália Tribuiani, Giovana Sabadim, Débora Antunes Neto Moreno, Eliana Aparecida Varanda, Yoko Oshima-Franco   +5 more
doaj   +1 more source

Screening for Ames mutagenicity of food flavor chemicals by (quantitative) structure-activity relationship

Genes and Environment, 2020
Background (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies.
Masamitsu Honma, Airi Kitazawa, Toshio Kasamatsu, Kei-ichi Sugiyama   +3 more
doaj   +1 more source

Mutagenic and Cytotoxic Activity of Insecticide Napoleon 4EC in Allium cepa and Ames Test

Caryologia, 2021
The objective of this study was to explore the mutagenic and cytotoxic effects of Napoleon 4EC pesticide used in Turkey to control insect pest by using two standard assays.
Dilek Akyıl
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source