Results 51 to 60 of about 27,055 (211)

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Safety evaluation of substituted thiophenes used as flavoring ingredients. [PDF]

, 2016
This publication is the second in a series by the Expert Panel of the Flavor and Extract Manufacturers Association summarizing the conclusions of its third systematic re-evaluation of the safety of flavorings previously considered to be generally ...
Bastaki, M, Cohen, SM, Fukushima, S, Gooderham, NJ, Guengerich, FP, Harman, CL, Hecht, SS, McGowen, MM, Rietjens, IM, Smith, RL, Taylor, SV, Valerio, LG   +11 more
core   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme [PDF]

, 2017
Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for mutagenicity.
Anderson, Diana, Anwar, Wagida A., Cimino, Michael C., Dobrev, Ivan, Douglas, George R., Eastmond, David A., Hartwig, Andrea, Nohmi, Takehiko, Phillips, David H., Vickers, Carolyn   +9 more
core  

Persistence of anticancer activity in berry extracts after simulated gastrointestinal digestion and colonic fermentation [PDF]

, 2012
Fruit and vegetable consumption is associated at the population level with a protective effect against colorectal cancer. Phenolic compounds, especially abundant in berries, are of interest due to their putative anticancer activity.
A Gil-Izquierdo, A Gonzalez-Sarrias, A Perez-Vicente, A Petermann, Alan Crozier, AM Aura, B Holst, BN Singh, C Manach, C Parr, C Zhao, Chris I. R. Gill, Derek Stewart, DY Shin, EM Brown, EM Coates, Emma M. Brown, FJ Reyes-Zurita, FJB van Duijnhoven, G Borges, G Lala, G Williamson, Gema Pereira-Caro, GJ McDougall, GJ McDougall, Gordon J. McDougall, Ian Rowland, IT Johnson, J Ferlay, J van Duynhoven, JR Pearson, JW Yun, LA Boyd, LS Adams, M Jenner A, M Sharma, Masaru Katoh, MJ Bermudez-Soto, MJ McCann, NP Seeram, P Ramnani, Pamela Magee, PDS Spada, Philip Allsopp, PN Chen, PS Makena, R González-Barrio, Rocio González-Barrio, S Ramos, S Roowi, S Thomasset, SJ Duthie, SR Sahasrabudhe, YZ Hashim   +53 more
core   +3 more sources

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Cardioprotective effect of spirulina on cafeteria diet‐induced cardiac injury in silico and in vivo study

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Obesity is a major risk factor for cardiovascular disease, primarily due to its effects on lipid metabolism, oxidative stress, and inflammation. The aim of this study was to evaluate the effects of spirulina (SP) on cafeteria diet (CD)‐induced myocardial oxidative stress and inflammation using biochemical, histological, and in ...
Fatma Arrari, Mohamed‐Amine Jabri, Imen Hammami, Hichem Sebai   +3 more
wiley   +1 more source

The Applicability of Software Tools for Genotoxicity and Carcinogenicity Prediction: Case Studies relevant to the Assessment of Pesticides [PDF]

, 2010
This report presents research results obtained in the framework of a project on the Applicability of Quantitative Structure-Activity Relationship (QSAR) analysis in the evaluation of the toxicological relevance of metabolites and degradates of pesticide ...
LAPENNA SILVIA, LO PIPARO ELENA, MOSTRAG-SZLICHTYNG A., SERAFIMOVA ROSITSA, WORTH Andrew   +4 more
core   +1 more source

Small molecules as arthropod kinin receptor antagonists, feeding modulators, or novel mosquitocidal agents

Pest Management Science, EarlyView.
A two‐pronged screen of small molecules – (1) on recombinant kinin receptor and (2) through topical application – identifies kinin receptor antagonists, feeding behavior modulators, and new mosquitocidal molecules. Abstract BACKGROUND Aedes aegypti and Culex quinquefasciatus mosquitoes are primary vectors for numerous human and animal pathogens and ...
Bianca M. Henriques‐Santos, Patricia V. Pietrantonio   +1 more
wiley   +1 more source

Genotoxicity profile of fexinidazole—a drug candidate in clinical development for human African trypanomiasis (sleeping sickness) [PDF]

, 2017
The parasitic disease human African trypanomiasis (HAT), also known as sleeping sickness, is a highly neglected fatal condition endemic in sub-Saharan Africa, which is poorly treated with medicines that are toxic, no longer effective or very difficult to
Bourdin Trunz, Bernadette, Torreele, Els, Tweats, David   +2 more
core