Results 51 to 60 of about 117,900,808 (282)

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Mutagenicity of Ochratoxin A and Its Hydroquinone Metabolite in the SupF Gene of the Mutation Reporter Plasmid Ps189

Toxins, 2012
Ochratoxin A (OTA) is a mycotoxin that enhances renal tumor formation in the outer medulla of male rat kidney. Direct DNA damage and subsequent mutagenicity may contribute to these processes. In this study we have determined whether OTA in the absence or
Richard A. Manderville, Gyungse Park, Steven A. Akman, Doug Case, Marissa Adams   +4 more
doaj   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Graphene quantum dots unraveling: Green synthesis, characterization, radiolabeling with 99mTc, in vivo behavior and mutagenicity

, 2019
International audienceGraphene is one of the crystalline forms of carbon, along with diamond, graphite, carbon nanotubes, and fullerenes, and is considered as a revolutionary and innovating product.
dos Santos, Clenilton Costa, Pinto, Suyene Rocha, Santos-Oliveira, Ralph, dos Reis, Sara Rhaissa Rezende, Araujo-Lima, Carlos Fernando, Helal-Neto, Edward, Nabiev, Igor, Do Vale Chaves E Mello, Francisco, Perini, Jamila Alessandra, de Menezes, Alan Silva, Machado, Daniel Escorsim, Saraiva-Souza, Aldilene, de Menezes, Frederico Duarte, Portilho, Filipe Leal, da Silva de Barros, Aline Oliveira, Alencar, Luciana Magalhāes Rebêlo, Felzenswalb, Israel, Sukhanova, Alyona   +17 more
core   +1 more source

Standard protocol for the total red blood cell Pig-a assay used in the interlaboratory trial organized by the Mammalian Mutagenicity Study Group of the Japanese Environmental Mutagen Society

Genes and Environment, 2019
The Pig-a assay, a promising tool for evaluating in vivo genotoxicity, is based on flow cytometric enumeration of red blood cells (RBCs) that are deficient in glycosylphosphatidylinositol anchor protein.
Satsuki Chikura, Takafumi Kimoto, Satoru Itoh, Hisakazu Sanada, Shigeharu Muto, Katsuyoshi Horibata   +5 more
doaj   +1 more source

Mutagenicity and genotoxicity of isatin in mammalian cells in vivo

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2011
Isatin (1H-indole-2,3-dione) is a synthetically versatile substrate used for the synthesis of heterocyclic compounds and as a raw material for drug synthesis. Isatin and its derivatives demonstrate anticonvulsant, antibacterial, antifungal, antiviral, and anticancer properties.
Candido-Bacani, Priscila de Matos, dos Reis, Mariana Bisarro, Serpeloni, Juliana Mara, Calvo, Tamara Regina, Vilegas, Wagner, Varanda, Eliana Aparecida, de Syllos Colus, Ilce Mara   +6 more
openaire   +3 more sources

Exploring traditional uses and biological activities related to liver cancer of Saban remedy extracts for potential liver cancer treatment [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Saban remedy is used at Khampramong Temple to relieve adverse effects in liver cancer patients. Aims: To analyze the taste and biological activities of Saban remedy and Cassia garrettiana as a principal component species in liver cancer ...
Naknarin Suchada, Itharat Arunporn, Wongpoomchai Rawiwan, Panthong Sumalee, Pipatrattanaseree Weerachai, Neal M. Davies, Loebenberg Raimar, Taya Sirinya, Phumlek Kalyarut, Intharit Ninnart, Ninlaor Theeraphong, Makchuchit Sunita, Kuropakornpong Pranporn, Pibanpaknitee Phrapaponpatchara, Tantitrakull Wilailuck, Mingmalairak Chatchai   +15 more
doaj   +1 more source

Antibacterial and antibiofilm activities of Prangos acaulis Bornm. extract against Streptococcus mutans: an in silico and in vitro study [PDF]

Journal of HerbMed Pharmacology, 2018
Introduction: Streptococcus mutans is a principal pathogenic agent in biofilm formation on the teeth surfaces and subsequently development of dental caries and plaque.
Mokhtar Nosrati, Mandana Behbahani, Hassan Mohabatkar, zahra shakeran   +3 more
doaj   +1 more source

Induction and Enhancement of Bacteriocin Production (Review)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley   +1 more source

The Assessment of the Biocompatibility of Dental Alloys and Alloys for Dental Amalgam. Part Second

Česká Stomatologie a Praktické Zubní Lékařství, 2014
Background: The second part of the literature review on the biocompatibility of dental alloys is focused to their possible sensibilizing effects, mutagenicity and carcinogenicity and the methods of their testing.
Z. Broukal, V. Fialová, J. Novotný
doaj   +1 more source