Results 61 to 70 of about 117,900,808 (282)

Scientific Opinion on Flavouring Group Evaluation 205 (FGE.205):Consideration of genotoxicity data on representatives for 13 α,β-unsaturated aliphatic ketones with terminal double bonds and precursors from chemical subgroup 1.2.2 of FGE.19 by EFSA [PDF]

EFSA Journal, 2012
<p>The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider in the Flavouring Group Evaluation 205, the additional data on genotoxicity submitted by the Industry ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

Statement on the mutagenicity of alcohol (ethanol) and its metabolite acetaldehyde. [PDF]

, 2016
This statement details the conclusions reached by the COM with regard to the published evidence on the genotoxicity and mutagenicity of ethanol, acetaldehyde and alcoholic beverages from January 2000 to May 2014, including the modifications made to the ...

core  

Click Bioconjugation of Aza‐BODIPY Fluorophores to LfcinB Peptides for Improved Biocompatibility

European Journal of Organic Chemistry, EarlyView.
Click bioconjugation attaches NIR aza‐BODIPY fluorophores to LfcinB‐derived anticancer peptides via CuAAC and thiol‐maleimide chemistry. Conjugates exhibit improved predicted solubility while retaining strong NIR absorption (703–730 nm). Peptide‐aza‐BODIPY conjugates induce apoptotic morphology in HeLa cancer cells.
A. Verónica Rodríguez‐Mayor, Maricela Morales, Héctor Manuel Pineda‐Castañeda, Zuly Jenny Rivera‐Monroy, Javier Eduardo García‐Castañeda, Norberto Farfán, Rosa Santillan   +6 more
wiley   +1 more source

Increased mutagenicity in the liver of MutaMouse females following oral treatment with commercial-grade toluene diisocyanate

Genes and Environment
Background Toluene diisocyanates (TDIs) are high-production-volume chemicals widely used in polyurethane manufacturing. A typical commercial-grade TDI (TDI; 2,4-toluene diisocyanate: 2,6-toluene diisocyanate; 80:20), CAS: 26471-62-5, is mutagenic in ...
Mariko Matsumoto, Masakatsu Natsume, Takako Iso, Takaaki Umano, Yasumasa Murata, Kenichi Masumura, Katsuyoshi Horibata, Kei-ichi Sugiyama   +7 more
doaj   +1 more source

Substituent effects on the in vitro and in vivo genotoxicity of 4-aminobiphenyl and 4-aminostilbene derivatives [PDF]

, 1994
4-Amino-4'-substituted biphenyls and 4-aminostilbenes substituted in the 3' or 4' position were studied for their in vitro and in vivo genotoxicity. The in vitro mutagenicity of the biphenyls with and without S9 activation was established with Salmonella
You, Zhengqing, Das, Salil K., Sinsheimer, Joseph E., Brezzell, M. D., Hooberman, Barry H.   +4 more
core   +1 more source

Food Safety Management and Mycotoxins Nexus: A Systematic Review of Mycotoxins Toxicity, Detoxification, Nutritional Impacts, and Economic Importance

Food Safety and Health, EarlyView.
The graphical abstract illustrates the interconnected relationship between food safety management, mycotoxin toxicity, and detoxification strategies, highlighting how preventive measures across the food chain can minimize mycotoxin contamination and reduce adverse health effects in humans/animals.
Chinaza Godswill Awuchi
wiley   +1 more source

Characterization and genotoxicity evaluation of effluent from a pharmacy industry

Revista Ambiente & Água, 2013
The pharmaceutical, textile and food industry bear much of the responsibility for environmental pollution. In order to appropriately treat and mitigate the effects of pharmaceutical effluent, it is necessary to study it in order to determine its physical
Hélio Mendes de Oliveira Júnior, Paulo de Tarso Ferreira Sales, Danyllo Bueno de Oliveira, Fernando Schimidt, Mariângela Fontes Santiago, Luiza Cintra Campos   +5 more
doaj   +1 more source

In vivo and in vitro effects of 3-methylcholanthrene on the microsome-mediated in vitro mutagenicity of 2-acetylaminofluorene.

, 1981
Pretreatment of rat, hamster or mouse by 3-methylcholanthrene (3-MC) largely induces the liver microsomal N-hydroxylase activity. The same pretreatment given simultaneously with 2-acetylaminofluorene (2-AAF) inhibits the hepatocarcinogenicity in the rat ...
Agazzi-Léonard, E, Razzouk, C., Roberfroid, Marcel, Mercier, Michel, Poncelet, F., Batardy-Gregoire, M   +5 more
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Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo

Brazilian Journal of Pharmaceutical Sciences, 2014
Flunitrazepam (FNZ) is a sedative benzodiazepine prescribed for the short-term treatment of insomnia. However, there are concerns regarding possible carcinogenic or genotoxic effects of this medicine.
Igor Vivian de Almeida, Giovana Domingues, Lilian Capelari Soares, Elisângela Düsman, Veronica Elisa Pimenta Vicentini   +4 more
doaj   +1 more source

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source