Results 81 to 90 of about 117,900,808 (282)

A toxicity profile of the Pheroid® technology in rodents

Toxicology Reports, 2019
The Pheroid® drug delivery system is now on the threshold of progressing into human clinical trials for various patented pharmaceutical applications and a systematic investigation of its toxicological properties in vitro and in vivo is thus a priority ...
Janke Kleynhans, Dale Elgar, Thomas Ebenhan, Jan Rijn Zeevaart, Awie Kotzé, Anne Grobler   +5 more
doaj   +1 more source

Inhibition of cyclophosphomide mutagenicity using Glycyrrihza glabra root extract [PDF]

, 2015
The aims of the studying is using methanolic - water extract of the Glycyrrihza glabra root for inhibition the mutagenicity of anticancer drug by cytogenetic assays in vivo in three interaction between the drug and extract.
Qasim M. Ali Al Ameri, Mona N. Al-Terehi, Ali H. Al Saadi and
core  

Mutagenicity of aliphatic epoxides

, 1978
The mutagenicity of 17 aliphatic epoxides was determined using the specially constructed mutants of Salmonella typhimurium developed by Ames. The activity of these epoxides together with those reported in the literature as mutagens in strains TA100 and ...
Airy, Subhash C., Sinsheimer, Joseph E., Wade, D. R.   +2 more
core   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Development, qualification, validation and application of the Ames test using a VITROCELL® VC10® smoke exposure system

Toxicology Reports, 2018
The Ames test has established use in the assessment of potential mutagenicity of tobacco products but has generally been performed using partitioned exposures (e.g. total particulate matter [TPM], gas vapor phase [GVP]) rather than whole smoke (WS).
Kathy Fowler, Wanda Fields, Victoria Hargreaves, Lesley Reeve, Betsy Bombick   +4 more
doaj   +1 more source

Bioassay-guided isolation and identification of antimutagenic compounds from Morina coulteriana and evaluation of its therapeutic potential

Phytomedicine Plus
Background: In the expanding field of cancer research, antimutagenic studies hold a promising ground. In recent times these studies have shown a shift towards the diverse flora of nature and its potential to treat cancer.
Jasbir Kour, Bashir Ahmad Lone, Amit Kumar, Bashir A. Ganai, Govind Yadav, Prasoon Gupta, Md.Niamat Ali, Seema Akbar   +7 more
doaj   +1 more source

Toxicological evaluation of standardized Kaempferia parviflora extract: Sub-chronic and mutagenicity studies

Toxicology Reports, 2019
Kaempferia parviflora (KP), also known as Krachai-dam in Thailand, belongs to the family Zingiberaceae and has been used traditionally to improve blood flow and treat inflammatory, allergic, and gastrointestinal disorders. The objective of this study was
Susumu Yoshino, Riyo Awa, Nobuaki Ohto, Yasuo Miyake, Hiroshige Kuwahara   +4 more
doaj   +1 more source

Mutagenicity of Water-Soluble ZnO Nanoparticles in Ames Test [PDF]

, 2009
A mutagenicity test was conducted on water-soluble ZnO nanoparticles capped with tetramethylammonium hydroxide in a bacterial reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537, and Escherichia coli strain WP2uvrA−,
Maenosono, Shinya, Kitamura, Daisuke, Yoshida, Rie   +2 more
core   +1 more source

UV mutagenesis‐enhanced Streptomyces nogalater produces a novel streptothricin‐like compound with strong activity against cabbage soft rot

Pest Management Science, EarlyView.
UV mutagenesis of Streptomyces sp. KRA0514‐6 yielded HL‐3, a novel streptothricin‐like compound (C17H29N7O8) with N‐methylglycine replacing β‐lysine, achieving 100% cabbage soft rot control at >1 ppm concentration. Abstract BACKGROUND A total of 1000 soil‐derived actinomycetes were isolated and screened for antibacterial activity against Pectobacterium
Young Sook Kim, Mirjalol Umurzokov, Hae Young Kim, Chun‐Zhi Jin, Eun Ae Kim, Kwang Min Cho   +5 more
wiley   +1 more source