Results 71 to 80 of about 117,900,808 (282)

Biological Effects of Selenium‐Containing Ionic Liquids: Cytotoxicity, Mercury Interaction, and Antiproliferative Activity in Glioblastoma Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Selenium (Se) is an essential micronutrient that participates in redox regulation and cellular homeostasis. Selenium‐containing ionic liquids (ILsSe) have emerged as hybrid compounds combining the properties of organoselenium molecules with the tunable features of ionic liquids.
Guilherme Schmitt Rieder, Alessandro de Souza Prestes, Fernanda D'Avila da Silva, Nilda de Vargas Barbosa, Alix Y. Bastidas Ángel, Mariana F. Soares, Carolina Martins Fernandes, Maria Anttônia Oliveira Petersen, Manuela Moura Silva, Juliete Nathali Scholl, Fabrício Figueiró, Pablo Andrei Nogara, Laura Orian, Eduardo E. Alberto, Michael Aschner, Diogo Onofre Gomes de Souza, Debora Guerini de Souza, João Batista Teixeira da Rocha   +17 more
wiley   +1 more source

Toxicology study profile of Nicotinamide mononucleotide after acute and 90-day sub chronic dosing in Wistar rats and mutagenicity tests

Current Research in Toxicology
Nicotinamide mononucleotide (NMN) is an intermediate in biosynthesis pathway of Nicotinamide adenine dinucleotide (NAD+), an essential cofactor in all living cells involved in fundamental biological processes.
Jianjun Yu, Qiang Shen, Jiayan Li
doaj   +1 more source

Air Pollution Quinones Impair Intestinal Barrier Integrity and Endoplasmic Reticulum in Differentiated Caco‐2 Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Particulate matter (PM) is a major global health threat, linked to millions of deaths annually. Beyond inhalation, PM components reach the gastrointestinal tract through the mucociliary escalator or contaminated food and water. Among PM's organic fraction, redox‐active quinones such as 1,2‐naphthoquinone (NQ) and 9,10‐phenanthrenequinone (PQ ...
Franco Cervellati, Giulia Trinchera, Alice Casoni, Alessandra Pecorelli, Mascia Benedusi, Maria Chiara Pietrogrande, Giuseppe Valacchi   +6 more
wiley   +1 more source

A Comprehensive Study to Compare Different Compound Representations for Predicting Carcinogenicity In Vivo

Journal of Applied Toxicology, EarlyView.
ABSTRACT Carcinogenicity evaluation is a critical component of chemical risk assessment, yet traditional in vivo testing remains time consuming, costly, and ethically challenging. Computational approaches based on machine learning offer promising alternatives, but the relative contributions of different molecular representation strategies for ...
Iuri Barbosa Pereira, Rogerio Salvini, Eloisa Dutra Caldas   +2 more
wiley   +1 more source

Genotoxicity profile of erinacine A-enriched Hericium erinaceus mycelium

Toxicology Reports, 2014
Hericium erinaceus (H. erinaceus) has a long history of usage in traditional Chinese medicine for the treatment of gastric disorders. Recently, it has become a well-established candidate in causing positive brain and nerve health-related activities by ...
I-Chen Li, Yen-Lien Chen, Wan-Ping Chen, Li-Ya Lee, Yueh-Ting Tsai, Chin-Chu Chen, Chin-Shuh Chen   +6 more
doaj   +1 more source

The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity.

, 2013
Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on 31their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for rel- 32evant toxicological endpoints to avoid ...
Rorije, E., Buist, H., Schüürmann, G., Escher, S., Aldenberg, T., Pauné, E., Batke, M., Kroese, D.E., Kühne, R., Marquart, H.   +9 more
core  

Dual Genotoxic and Antigenotoxic Effects of 3‐Benzoylcoumarins in Mammalian Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are phenolic compounds widely recognized for their diverse pharmacological activities and have attracted increasing attention as potential chemopreventive agents. In the present study, four known 3‐benzoylcoumarin derivatives [(1), (2), (3), and (4)] were evaluated for their cytotoxic, mutagenic, and antigenotoxic effects in Chinese ...
Leticia Helena Parreira, Evelyn Pinheiro de Mendonça, Aléxia Polo Siqueira, Cleydson Finotti Cordeiro, Elkin José Torres Sierra, Rudy Bonfilio, Diogo Teixeira Carvalho, Pollyanna Francielli de Oliveira   +7 more
wiley   +1 more source

Toxicological Evaluation of Low Molecular Weight Fucoidan in Vitro and in Vivo

Marine Drugs, 2016
For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products.
Pai-An Hwang, Ming-De Yan, Hong-Ting Victor Lin, Kuan-Lun Li, Yen-Chang Lin   +4 more
doaj   +1 more source

High‐Content Screening Comparison of 1R6F Cigarette Smoke Extract and Selected Heated Tobacco and Electronic Vapour Product Aerosol Extracts in Endothelial and Bronchial Epithelial Cell Models

Journal of Applied Toxicology, EarlyView.
ABSTRACT Cigarettes induce oxidative stress and DNA damage, processes that contribute to cardiovascular and pulmonary disease. High content screening (HCS) is an increasingly valuable tool for comparative toxicology because it enables simultaneous quantification of multiple mechanistic endpoints at single‐cell resolution. In this study, HCS was used to
Edgar Trelles Sticken, Konstantinos Papikinos, Fiona Chapman, Roman Wieczorek, Sarah Jean Pour, Torge Evenburg, Sandra Otte, Tiandan Wu, Liam Simms, Matthew Stevenson   +9 more
wiley   +1 more source

Corrigendum: Biomolecules as Model Indicators of In Vitro and In Vivo Cold Plasma Safety

Frontiers in Physics, 2021
Caitlin Heslin, Daniela Boehm, Brendan F. Gilmore, Julianne Megaw, Theresa A. Freeman, Noreen J. Hickok, P. J. Cullen, P. J. Cullen, Paula Bourke, Paula Bourke, Paula Bourke   +10 more
doaj   +1 more source