Results 91 to 100 of about 117,900,808 (282)

Development of Structural Alerts for the In Vivo Micronucleus Assay in Rodents [PDF]

, 2009
In vivo mutagenicity and carcinogenicity studies are posing a high demand for test-related resources. Among these studies, the micronucleus test in rodents is the most widely used, as follow up to positive in vitro mutagenicity results.
BENIGNI Romualdo, BOSSA Cecilia, TCHEREMENSKAIA Olga, WORTH Andrew   +3 more
core   +2 more sources

Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium

, 1996
The rat theta class glutathione S-transferase (GST) 5-5 has been shown to affect the mutagenicity of halogenated alkanes and epoxides. In Salmonella typhimurium TA1535 expressing the rat GST5-5 the number of revertants was increased compared to the ...
Ketterer, Brian, Guengerich, F. Peter, Thier, Ricarda, Taylor, Jennifer, Kramer, Harry, Pemble, Sally E.   +5 more
core   +1 more source

Catechins and Their Effect on the Gut Microbiome in Health and Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Catechins are a group of flavonoids found primarily in green tea, fruits, and berries; they play a significant role in the modulation of the gut microbiota, thereby having an impact on gut health and cancer prevention. Owing to their low bioavailability, catechins are transformed by the gut microbiota into various bioactive metabolites such as
Prakash Monika, Bindu Sadanandan, Honnamachanahalli Ramachandraiah Tejashree, Maitreyi Darbha, Kirti Gupta, Srinivas Reneeka   +5 more
wiley   +1 more source

Beyond Removal Efficiency: Environmental Risk Assessment of Tartrazine Degradation via ZnO and TiO2 Nanoparticles in Mussels

Environmental Toxicology, EarlyView.
ABSTRACT Tartrazine (TZ) is a widely used synthetic azo dye with high aqueous stability, resulting in persistence in wastewater. Photoreactive nanomaterials, principally zinc oxide (ZnO) and titanium dioxide (TiO2) nanoparticles (NPs), are frequently employed for dye removal under light‐exposed conditions; nevertheless, their ecotoxicological ...
İrem Can, Ezgi Can Güzel, Volkan Saritunç, Selin Ertürk Gürkan   +3 more
wiley   +1 more source

Establishing a quantitative framework for regulatory interpretation of genetic toxicity dose-response data: Margin of exposure case study of 48 compounds with both in vivo mutagenicity and carcinogenicity dose-response data. [PDF]

Environ Mol Mutagen, 2023
Chepelev N, Long AS, Beal M, Barton-Maclaren T, Johnson G, Dearfield KL, Roberts DJ, van Benthem J, White P.   +8 more
europepmc   +1 more source

vivo-project/VIVO: Release vivo-1.14.1

<p><strong>Release vivo 1.14.1</strong><br/>It is recommended that you review the 1.14 Documentation and the VIVO/Vitro READMEs on github before you start.<br/>If you are new to VIVO/Vitro it is suggested that you take ...
Jim Blake, Stefan-Wolff, Brian Caruso, Andrew Woods, Nate Prewitt, William Welling, Don Elsborg, hudajkhan, Ralph O'Flinn, Georgy Litvinov, Alex Viggio, tworrall, Ben, Ted Lawless, Miloš Popović, Arfon Smith, vivo-uab, Jon Corson-Rikert, Steve McKay, Mike Conlon, Dragan Ivanovic, hauschke, Brian Lowe, Stephen V. Williams, Holly Mistlebauer, Michel Héon, Laura Wrubel, Graham Triggs   +27 more
core   +1 more source

In silico exploratory study using structure–activity relationship models and metabolic information for prediction of mutagenicity based on the Ames test and rodent micronucleus assay

, 2015
The mutagenic potential of chemicals is a cause of growing concern, due to the possible impact on human health. In this paper we have developed a knowledge-based approach, combining information from structure–activity relationship (SAR) and metabolic ...
P. Kamath (825839), R. Rallo (824049), G. Raitano (825840), E. Benfenati (682162), A. Fernández (825841)   +4 more
core   +1 more source

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Evaluation of Hirsutella sinensis Mycelium on Food Safety and Anti-hepatoma Activity in an Animal Model.

, 2014
[[abstract]]There is evidence that Hirsutella sinensis may have antitumor activity. The aim of the present study was to determine the anti-hepatoma effects and food safety assessment of Hirsutella sinensis mycelium in vivo and in vitro.
HUNG-SHENG, S;SHANG, HUNG-SHENG;CHOU, JASON;CHOU, JASON;MING-FANG, WU;MING-FANG, WU;YUNG-LUEN, SH;SHIH, YUNG-LUEN;MING-YANG, YE;YEH, MING-YANG;CHU, HSUEH-YU;CHUNG, HSUEH-YU;HSU-FENG, LU;HSU-FENG, LU;NIEN-CHIEH, L;LIAO, NIEN-CHIEH;鍾景光*
core  

Establishment of a Human Cell‐Based In Vitro Test System for Investigating and Evaluating Cytotoxic and Immunomodulatory Effects of Indoor Mold

Environmental Toxicology, EarlyView.
ABSTRACT Mold growth in damp indoor environments is a widespread problem associated with respiratory health effects, though causal mechanisms remain incompletely understood. We established a human cell‐based in vitro test system using bronchial epithelial cells (NuLi‐1) and macrophages (THP‐1) to assess inhalation toxicity and immunomodulatory effects ...
Anja Wolff, Jessica Reinert, Silke Steinborn, Marion Berger, Judith Neuhoff, Lennart Marske, Kerttu Valtanen, Udo Jäckel, Stefanie Klar   +8 more
wiley   +1 more source