Cell Proliferation, Volume 59, Issue 5, May 2026.AAV's widespread application is currently confronting critical challenges. This study established a systematic framework of ‘natural discovery–evolutionary analysis–functional optimization’, providing a new paradigm for the development of next‐generation AAV vectors with clinical‐grade tissue specificity, low immunogenicity, and cross‐species ...
Liyu Zhu +11 more
wiley +1 more source
A Single‐Base Mutation in TaWAK3‐B Reduces Plant Height via Cytoskeleton in Bread Wheat
Plant Biotechnology Journal, Volume 24, Issue 5, Page 3261-3278, May 2026.ABSTRACT Introduction of Reduced height (Rht) genes into modern wheat cultivars has resulted in ‘Green Revolution’ that skyrocketed wheat grain yields worldwide since the 1960s. These ‘Green Revolution’ cultivars show shorter plant height, but higher lodging resistance and harvest index.
Naijiao Wang +16 more
wiley +1 more source
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and mutagenic activity in Massachusetts drinking water. [PDF]
, 2011 There is limited information on the prevalence of the potent mutagen 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in U.S. water supplies. We measured MX concentrations and mutagenic activity in tap water samples from 36 surface water systems
Altshul, Larisa M. +6 more
core
The 2024 European Union report on pesticide residues in food
EFSA Journal, Volume 24, Issue 5, May 2026.Abstract Under European Union legislation (Article 32, Regulation (EC) No 396/2005), the European Food Safety Authority publishes an annual report assessing pesticide residue levels in food. In 2024, 9842 samples were analysed as part of the EU‐coordinated multiannual control programme subset, of which 1.2% were found to be non‐compliant.
European Food Safety Authority (EFSA) +4 more
wiley +1 more source
Development of reclaimed potable water quality criteria [PDF]
In order to minimize launch requirements necessary to meet the demands of long-term spaceflight, NASA will reuse water reclaimed from various on-board sources including urine, feces, wash water and humidity condensate.
Flory, D. A., Weir, F. W.
core +1 more source
Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits
ChemMedChem, Volume 21, Issue 7, 14 April 2026.A multistep virtual screening cascade, integrating shape‐based, ensemble docking, and quantitative structure–activity relationship (QSAR) models, was employed to screen 1.5 million compounds. This funnel identified a novel 3‐chymotrypsin‐like protease (3CLpro) inhibitor, LabMol‐499, which was experimentally validated using a Förster Resonance Energy ...
Sabrina Silva‐Mendonça +14 more
wiley +1 more source
Flavonoid Oxime Carbamate Derivatives: Reversal of Multidrug Resistance in Cancer Cells
ChemMedChem, Volume 21, Issue 7, 14 April 2026.A set of 23 new flavonoid oxime carbamates was synthesized and evaluated as multidrug resistance (MDR) reversers in ABCB1‐transfected mouse lymphoma cells. All derivatives strongly inhibited P‐glycoprotein (P‐gp) efflux activity in a transport assay, while most selected compounds behaved as ATPase inhibitors. In drug combination assays, they interacted
Filipa Barbosa +5 more
wiley +1 more source
Mechanisms of oxidative stress-induced in vivo mutagenicity by potassium bromate and nitrofurantoin. [PDF]
J Toxicol Pathol, 2018 Tsuchiya T +7 more
europepmc +1 more source
Lack of in vivo mutagenicity of carbendazim in the liver and glandular stomach of MutaMice. [PDF]
Genes EnvironIso T +9 more
europepmc +1 more source
Therapeutic potential of Brazilian medicinal plants and their metabolites. [PDF]
Genet Mol BiolSerpeloni JM +3 more
europepmc +1 more source