Results 11 to 20 of about 117,900,808 (282)
In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde [PDF]
Genes and Environment, 2021 Background Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA reactive. Indeed, several reports
Masamitsu Honma +5 more
doaj +3 more sources
Absence of mutagenicity of plants used to treat gastrointestinal disorders [PDF]
Archives of Biological Sciences, 2013 The Brazilian Savanna (locally called “Cerrado”) is an important biome presenting several plants that are used in popular medicine. However, the risks associated with the consumption of derivatives from these plants are generally unknown. Studies with
Santos F.V. +6 more
doaj +4 more sources
Mutagenicity and teratogenicity studies of vitacoxib in rats and mice
Toxicology Reports, 2018 Vitacoxib is a new drug candidate for treatment of inflammation, pain and fever as selective cyclooxygenase-2 inhibitors. In the current study, the mice sperm abnormality, mammalian erythrocyte micronucleus and in vivo chromosome aberration, and ...
Jianzhong Wang +5 more
doaj +2 more sources
Mutagenicity of Chinese traditional medicine Semen
BMC Complementary and Alternative Medicine, 2009 Background Semen armeniacae amarum (SAA) is a Chinese traditional medicine and has long been used to control acute lower respiratory tract infection and asthma, as a result of its expectorant and antiasthmatic activities.
Cai Yupin +5 more
doaj +2 more sources
Genetics and Molecular Biology, 2005 Cashew (Anacardium occidentale) is a medicinal plant native to Brazil and also yields a nutritious fruit juice. Its large pulpy pseudo-fruit, referred to as the cashew apple, contains high concentrations of vitamin C, carotenoids, phenolic compounds and ...
Ana Amélia Melo Cavalcante +4 more
doaj +2 more sources
Benchmark Response (BMR) Values for In Vivo Mutagenicity Endpoints. [PDF]
Environ Mol MutagenThe benchmark dose (BMD) approach constitutes the most effective and pragmatic strategy for the derivation of a point of departure (PoD) for comparative potency analysis, risk assessment, and regulatory decision‐making.
White PA +8 more
europepmc +2 more sources
A test of the mutagenicity of cooked meats in vivo [PDF]
Mutagenesis, 2001 There is a correlation between intestinal cancer and diets high in meat, so fried beef, chicken, lamb, pork and fish were tested for their ability to induce mutations in the small intestine of mice. The mice were bred to be heterozygous at the Dlb-1 locus so that loss of the dominant Dlb-1 b allele by mutation could be detected.
J A, Heddle +3 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode +16 more
wiley +1 more source
The OSIRIS weight of evidence approach: ITS mutagenicity and ITS carcinogenicity
, 2022 S.170-181Risk assessment of chemicals usually implies data evaluation of in vivo tests in rodents to conclude on their hazards. The FP7 European project OSIRIS has developed integrated testing strategies (ITS) for relevant toxicological endpoints to ...
Pauné, Eduard +10 more
core +1 more source
The Degradation Product of Ramipril Is Potentially Carcinogenic, Genotoxic and Mutagenic
Applied Sciences, 2023 (1) Background: The aim of this study was to identify the degradation product of ramipril (RAM) formed under dry air and to verify its potential modes of carcinogenicity. We intended to check whether its formation and presence in final dosage forms could
Katarzyna Regulska +3 more
doaj +1 more source