Results 21 to 30 of about 117,900,808 (282)
CDK8/19 inhibition plays an important role in pancreatic β-cell induction from human iPSCs
Stem Cell Research & Therapy, 2023 Background Transplantation of differentiated cells from human-induced pluripotent stem cells (hiPSCs) holds great promise for clinical treatments. Eliminating the risk factor of malignant cell transformation is essential for ensuring the safety of such ...
Kensuke Sakuma +11 more
doaj +1 more source
Toxicology Reports, 2022 The 12.4 kDa fungal immunomodulatory protein from Ganoderma microsporum (GMI) has bioactivity in vitro and in vivo. This study assessed the safety of GMI derived from engineered Pichia pastoris in Sprague-Dawley rats as a dietary supplement and food ...
Hsu-Yuan Fu, Ruey-Shyang Hseu
doaj +1 more source
In vivo mutagenicity of conazole fungicides correlates with tumorigenicity [PDF]
Mutagenesis, 2008 Triadimefon, propiconazole and myclobutanil are conazoles, an important class of agricultural and therapeutic fungicides. Triadimefon and propiconazole are mouse liver tumorigens, while myclobutanil is not. All three conazoles are generally inactive in short-term genotoxicity tests. We studied the in vivo mutagenicity of these three conazoles using the
Jeffrey A, Ross +2 more
openaire +2 more sources
Scientific Reports, 2021 Mutagenicity exerts adverse effects on humans. Conventional methods cannot simultaneously predict the toxicity of a large number of compounds. Most mutagenicity prediction models are based on a single experimental type and lack other experimental ...
Xiaotong Yang +3 more
doaj +1 more source
In Vitro versus In Vivo Metabolic Activation of Mutagens [PDF]
Environmental Health Perspectives, 1973 Mutagenicity testing is beginning to find a place as a factor in evaluation of the safety of compounds to which the human population is exposed. The mutation systems selected for such tests should ideally involve in vivo studies with mammals and encompass scoring of a broad spectrum of mutational events including both transmissible chromosome ...
H V, Malling, C N, Frantz
openaire +2 more sources
Multi-Task Deep Neural Networks for Ames Mutagenicity Prediction [PDF]
, 2022 The Ames mutagenicity test constitutes the most frequently used assay to estimate the mutagenic potential of drug candidates. While this test employs experimental results using various strains of Salmonella typhimurium, the vast majority of the published
Nuria E., Campillo +15 more
core +2 more sources
Genes and Environment, 2018 Background Previously we found that DNA adducts were accumulated in the lungs of the rats exposed to ambient air in the Tokyo metropolitan area. To examine chronological change in in vivo mutagenicity of airborne particles, extracts produced from samples
Yasunobu Aoki +8 more
doaj +1 more source
Mutagenicity and safety pharmacology of a standardized antidiabetic polyherbal formulation
Scientific Reports, 2022 Synacinn is a standardized polyherbal extract formulated for the treatment of diabetes mellitus and its complications. This study aims to assess the mutagenicity potential of Synacinn by Ames assay and in vivo bone marrow micronucleus (MN) test on ...
Fadzilah Adibah Abdul Majid +7 more
doaj +1 more source
Hepatotoxicity and Mutagenicity assessment during chronic in vivo exposure to aqueous extracts from Peperomia pellucida [PDF]
Anais da Academia Brasileira de Ciências, 2022 Studies on herbal medicine have exposed some toxic effects on humans. Peperomia pellucida (L.) HBK (P. pellucida) is one of the herbal medicines recommended as an alternative to synthetic medicine for diseases.
YU-WEN HUANG +2 more
doaj +1 more source
ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives [PDF]
, 1993 Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobenzidine were compared for their in vitro and in vivo ...
You, Zhengqing +5 more
core +1 more source