Results 131 to 140 of about 25,307,067 (306)
Information Interface - Volume 3, Issue 4 - September 1978 [PDF]
, 1978 News and information about Himmelfarb Health Sciences Library of interest to ...
George Washington University, Himmelfarb Health Sciences Library
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Information Interface - Volume 36, Issue 3 - August/September 2008 [PDF]
, 2008 News and information about Himmelfarb Health Sciences Library of interest to ...
George Washington University, Himmelfarb Health Sciences Library
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Information Interface - Volume 20, Issue 2 - May/June 1995 [PDF]
, 1995 News and information about Himmelfarb Health Sciences Library of interest to ...
George Washington University, Himmelfarb Health Sciences Library
core
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Information Interface - Volume 3, Issue 3 - June 1978 [PDF]
, 1978 News and information about Himmelfarb Health Sciences Library of interest to ...
George Washington University, Himmelfarb Health Sciences Library
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Information Interface - Volume 18, Issue 2 - March/April 1994 [PDF]
, 1994 News and information about Himmelfarb Health Sciences Library of interest to ...
George Washington University, Himmelfarb Health Sciences Library
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source