Results 61 to 70 of about 2,378,423 (314)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Frontiers in Public HealthBackgroundField Epidemiology Training Programs (FETPs) are a core element of applied epidemiology capacity worldwide. FETPs in the Middle East and North Africa (MENA) region, have repeatedly demonstrated their value during public health emergencies ...
Engy M. El-Ghitany +3 more
doaj +1 more source
From Middle to Shaky Ground: The Economic Decline of America's Middle Class [PDF]
, 2008 A middle-class standard of living requires that families have adequate financial security to meet current obligations, invest in the future, and access opportunities.
Jennifer Wheary +3 more
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Human Biology and Public HealthHealth security is a vital pillar of German national security. While the COVID-19 pandemic was a stress test, high expenditure failing to yield superior health outcomes reveals structural inefficiency in the German healthcare system.
Leif Erik Sander
doaj +1 more source
From global health security to global health solidarity, security and sustainability
Bulletin of the World Health Organization, 2016 The concept of global health security underpins the current framework for global preparedness and response to emerging infectious diseases. (1-5) The Global Health Security Agenda--a collaboration between governments--was launched in 2014, aiming to make our interconnected world safe from infectious disease threats.
Flahault, Antoine +3 more
openaire +6 more sources
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Human trafficking and human (in)security [PDF]
Megatrend RevijaThe paper focuses on exploring the impact of human trafficking on human security. The primary research method employed is a review of scholarly literature.
Pajić Nataša
doaj +1 more source
Public Health Provisions of the Social Security Act [PDF]
, 1936 This paper analyses the survival of four different growth regimes conditional on political regime transitions that occurred during the first or prior year of the economic regime.
Sydenstricker, Edgar
core +1 more source