Results 41 to 50 of about 1,816,296 (269)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

District-based Health Services

South African Family Practice, 1995
No abstract available.
M.S. Blecher, I.G. Frankish
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Case validation of bloodstream infections with an antibiotic-resistant organism

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Bloodstream infections (BSIs) are an important cause of morbidity and mortality in severely ill patients, contributing to increased length of hospital stay and higher cost of care. Alberta Health Services Infection Prevention and Control (IPC)
Jennifer Ellison, Blanda Chow, Andrea Howatt, Logan Armstrong, Ted Pfister, Zhe Lu, Kathryn Bush   +6 more
doaj   +1 more source

Adapting Community Health Worker Care Models to Advance Mental Health Services Among LGBTQ Youth [PDF]

, 2023
Miya L. Barnett, Hanan Salem, Yessica Green Rosas, Emily Feinberg, Rocio Nunez-Pepen, Andrea Chu, Hana Belmont-Ryu, Em Matsuno, Sarabeth Broder‐Fingert   +8 more
openalex   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Low-Dose Clozapine Reduces Aggression in Violent Substance Use Disorder Patients at a Secure Rehabilitation Center

Case Reports in Psychiatry
Managing aggressive behaviors in patients with substance use disorders (SUDs), particularly when accompanied by comorbid psychiatric disorders, presents considerable challenges.
Suhair Mohammed Yousuf, Abdelrahman Zohir Khaled Eldous, Faycal Walid Ikhlef, Nirvana Swamy Kudlur Chandrappa, Majid Ali Y. A. Al Abdulla   +4 more
doaj   +1 more source

Timely data on the dynamic drug supply is crucial in addressing the ongoing drug poisoning crisis. The team is exploring ways to share information with emergency responders, healthcare providers, government officials, and pwSUD.

International Journal of Population Data Science
Objective Transitioning from hospitals to primary care brings significant challenges, including increased readmission rates, mortality, and costs due to information gaps.
Tanmay Patil, Robin Walker, Congshi Shi, Wanning Song, Judy Seidel, Scott Oddie   +5 more
doaj   +1 more source

Characterization of Home Care Services and care for children with special health care needs [PDF]

, 2022
Diana Augusta Tres, Rafael Gué Martini, Beatriz Rôsana Gonçalves de Oliveira Toso, Elisângela Argenta Zanatta   +3 more
openalex   +1 more source