Results 61 to 70 of about 17,124,068 (312)

Low-Dose Clozapine Reduces Aggression in Violent Substance Use Disorder Patients at a Secure Rehabilitation Center

Case Reports in Psychiatry
Managing aggressive behaviors in patients with substance use disorders (SUDs), particularly when accompanied by comorbid psychiatric disorders, presents considerable challenges.
Suhair Mohammed Yousuf, Abdelrahman Zohir Khaled Eldous, Faycal Walid Ikhlef, Nirvana Swamy Kudlur Chandrappa, Majid Ali Y. A. Al Abdulla   +4 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Northern Territory women's health services discussion paper

, 1990
Health care services in the Northern Territory have been developed over the years to ensure a high standard and quality of care is accessible and equitably distributed to all Territorians.
Northern Territory Department of Health and Community Services
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College of Health & Human Services professional schools

, 2020
Within the College of Health and Human Services (CHHS), three professional schools integrate teaching, community outreach, and research--the School of Health and Applied Human Sciences, the School of Nursing, and the School of Social ...
University of North Carolina, Wilmington. College of Health and Human Services
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Case validation of bloodstream infections with an antibiotic-resistant organism

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Bloodstream infections (BSIs) are an important cause of morbidity and mortality in severely ill patients, contributing to increased length of hospital stay and higher cost of care. Alberta Health Services Infection Prevention and Control (IPC)
Jennifer Ellison, Blanda Chow, Andrea Howatt, Logan Armstrong, Ted Pfister, Zhe Lu, Kathryn Bush   +6 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Working across health services and academia: challenges and solutions for health research [PDF]

, 2019
This report presents the proceedings of an Irish Health Research Forum event held on November 13th 2019 on the challenges and potential solutions for researchers working across health services and academia. It also makes key recommendations for improving
Health Research Charities Ireland
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Timely data on the dynamic drug supply is crucial in addressing the ongoing drug poisoning crisis. The team is exploring ways to share information with emergency responders, healthcare providers, government officials, and pwSUD.

International Journal of Population Data Science
Objective Transitioning from hospitals to primary care brings significant challenges, including increased readmission rates, mortality, and costs due to information gaps.
Tanmay Patil, Robin Walker, Congshi Shi, Wanning Song, Judy Seidel, Scott Oddie   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source