Results 71 to 80 of about 2,534,664 (269)
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Parents and Children Together: Design and Implementation of Two Healthy Marriage Programs [PDF]
, 2016 The Parents and Children Together (PACT) evaluation, conducted by Mathematica Policy Research for the Office of Research, Planning, and Evaluation, Administration for Children and Families (ACF), U.S. Department of Health and Human Services, is examining
Heather Zaveri, Scott Baumgartner
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Comparative life expectancy in Africa [PDF]
For health outcomes, is poverty destiny? The authors explore this question for life expectancy in Africa, where health outcomes are positively correlated with income, but where the link is far from uniform.
McCarthy, F. Desmond, Wolf, Holger
core
Economic evaluation: what does a nurse manager need to know?
, 2005 This paper considers how health economists can assist nurse managers, using the concepts and tools of economic evaluation. We aim to clarify these and also explode some of the myths about economic evaluation and its role in health care decision-making ...
Douglas, Hannah-Rose, Normand, Charles
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Diabetes policies and pharmacy-based diabetes interventions in Portugal: a comprehensive review
Journal of Pharmaceutical Policy and Practice, 2019 Background Pharmacy-based interventions are complex public health endeavors which include, but are not restricted to, the conventional medication supply role. In diabetes, such interventions may improve patients’ outcomes.
Suzete Costa +9 more
doaj +1 more source
Optimizing Outreach and Application Assistance Services in Community-based Organizations: Evaluation Findings from The Colorado Trust's Outreach and Enrollment for Children and Youth Grant Strategy [PDF]
, 2013 This report discusses findings from the evaluation of The Colorado Trust's three-year, $3.3 million grant strategy (2009-2011) to help expand enrollment of children and youth in public health insurance programs in Colorado. These findings focus on how 12
Catia Chavez +3 more
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Is a Decentralised Health Policy Associated With Better Self-rated Health and Health Services Evaluation? A Comparative Study of European Countries. [PDF]
Int J Health Policy Manag, 2021 Martinussen PE, Rydland HT.
europepmc +1 more source