Results 81 to 90 of about 19,960,223 (305)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Adverse childhood experiences and adverse community environments among maternal mortality cases in Arizona

The Journal of Maternal-Fetal & Neonatal Medicine
Background Adverse childhood experiences (ACE) and adverse community environments (ACoE) can have negative impacts on adult health and lead to premature death. Their association within the maternal mortality (MM) population remains unknown.Objective This
Sarah E. Kellerhals, Bin Suh, Vivienne Rubio, Martin F. Celaya, Glenda M. Ramirez, Kendra M. Gray   +5 more
doaj   +1 more source

Community health program evaluation report : October 1993 to June 1997

, 1997
Evaluation Report of the Community Health Program undertaken in response to the requirements of the Financial Management Act 1995 and Treasurer's Directions 3.4.
Community Health Program Review Team
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Techniques to tell the real story: narrative inquiry in health services research [PDF]

, 2014
Fifteen years ago in Health Services Research (1999) qualitative research methods were argued to be useful and valid. Since that time qualitative research methods have gained increasing legitimacy however qualitative research papers remain ...
Cusick, Anne, Rosalind A Bye, Bye, Rosalind A. (R7363), Ison, Nicole L. (R18452), Anne Cusick, Nicole Ison   +5 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Effectiveness of a decision aid for promoting colorectal cancer screening in Spain: a randomized trial

BMC Medical Informatics and Decision Making, 2019
Background Colorectal cancer (CRC) screening has shown to reduce incidence and mortality rates, and therefore is widely recommended for people above 50 years-old.
Lilisbeth Perestelo-Perez, Amado Rivero-Santana, Alezandra Torres-Castaño, Vanesa Ramos-Garcia, Yolanda Alvarez-Perez, Nerea Gonzalez-Hernandez, Andrea Buron, Michael Pignone, Pedro Serrano-Aguilar   +8 more
doaj   +1 more source

Environmental health services in Europe 5: guidelines for evaluation of environmental health services

, 2000
viii, 185 p.This publication provides a practical guide to concepts, methods and instruments for conducting an evaluation of environmental health services.
Bonnefoy, Xavier, Drew, Christina H, van Duivenboden, Jaco   +2 more
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Learning from partnership in the health services

, 2008
The need for measurement and evaluation of workplace partnership processes is explicitly stated in both the Health Services Partnership Agreement and the Action Plan for People Management.
Health Services National Partnership Forum (HSNPF)
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