Results 61 to 70 of about 1,684,609 (311)

Low-level support for socially isolated older people: An evaluation of telephone befriending [PDF]

open access: yes, 2008
In May 2005 Help the Aged and Zurich Community Trust launched a two year national programme ‘A Call in Time’. The purpose of the programme was to provide low level support and befriending services via the telephone to older people who are lonely ...
Bagnall, A, Cattan, M, Kime, NH
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1626-1642, June 2026.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

The GP's role in continuing care for the aged: A commitment to holistic care

open access: yesSouth African Family Practice, 1986
No abstract available.
M.V. Silbert
doaj   +1 more source

Non-Emergency Medical Transportation Needs of Middle-Aged and Older Adults: A Rural-Urban Comparison in Delaware, USA. [PDF]

open access: yes, 2017
Background: Older adults in rural areas have unique transportation barriers to accessing medical care, which include a lack of mass transit options and considerable distances to health-related services.
Eisenstein, Amy R   +8 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1473-1493, June 2026.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Comparative study of elderly care services among Iran, United States of America, and Sweden

open access: yesمجله علمی دانشگاه علوم پزشکی کردستان, 2020
Background and Aim: According to statistics, the world is rapidly moving towards aging. The aim of this study was to compare United States of America, Sweden and Iran in regard to population aging status, types of aged care services and types of aged ...
Nasrin Shaarbafchi Zadeh   +3 more
doaj  

Functionality and cognition of older adults hospitalized in a university hospital [PDF]

open access: yesRevista Brasileira de Enfermagem
Objectives: to verify the association between functionality, cognitive function, and age group among hospitalized older adults. Methods: this was a descriptive and cross-sectional study conducted with patients hospitalized in the adult/older adult ...
Felipe Bueno da Silva   +3 more
doaj   +1 more source

Injection of clarity needed? [PDF]

open access: yes, 2003
The legal status of children who stay in hospital for three months or longer gives rise to considerable confusion among managers in social services and social work departments. And the number of young people affected is significant.
Carpenter, J.   +3 more
core   +1 more source

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