Results 81 to 90 of about 1,684,609 (311)

Avaliação das instituições de longa permanência para idosos do município de Olinda-PE

Revista Brasileira de Geriatria e Gerontologia
OBJETIVO: Este trabalho se propõe a analisar a organização e funcionamento das instituições de longa permanência para idosos (ILPI) do município de Olinda-PE, através da aplicação do instrumento específico da Vigilância Sanitária, elaborado em 2007 ...
Barbara Helena de Brito Angelo, Débhora Isis Barbosa e Silva, Maria do Amparo Souza Lima   +2 more
doaj   +1 more source

The mental health of children and adolescents: report on the second Australian child and adolescent survey of mental health and wellbeing [PDF]

, 2015
FOREWORD This report provides compelling reading for everyone interested in the health and wellbeing of Australian children and adolescents. Based on a survey conducted in the homes of over 6,300 families with children and/or adolescents aged 4 to 17 ...
David Lawrence, Jennifer Hafekost, John Ainley, Katrina Boterhoven de Haan, Michael Sawyer, Sarah Johnson, Stephen R. Zubrick   +6 more
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Training for dementia care and support in rural and remote Australia: appraisals from a nationwide workforce survey

BMC Geriatrics
Background Dementia is a growing challenge to health and aged care worldwide and is the leading cause of disease burden in older Australians. High-quality person-centred care of people with dementia and support for their family caregivers require a ...
John A. Woods, Jessica Valentine, Kira Gusterson, Kathryn W. Fitzgerald, Katrina P. Fyfe, Myles Clarkson Fletcher, Mohammad Hamiduzzaman, Pascale Dettwiller, Anthony B. Fallon, Clare Dal Bon, Sarah E. Miles, Jo-Anne W. Rayner, Sandra C. Thompson   +12 more
doaj   +1 more source

Acute Myocardial Infarction in Older Adult Patients [PDF]

Geriatrics, Gerontology and Aging
OBJECTIVES: To assess clinical and coronary angiographic characteristics, previous medical history, and clinical course, by age group, in older adults after myocardial infarction who underwent primary percutaneous coronary intervention (pPCI).
Marcia Moura Schmidt, Cristina Klein Weber, Carlos Antonio Mascia Gottschall, Alexandre Schaan de Quadros   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Young people's use of NHS Direct: a national study of symptoms and outcome of calls for children aged 0-15 [PDF]

, 2013
Objectives National Health Service (NHS) Direct provides 24/7 expert telephone-based healthcare information and advice to the public in England. However, limited research has explored the reasons to why calls are made on behalf of young people, as such ...
Chater, Angel, Cook, Erica Jane, Guppy, Andy, Large, Shirley, O'Mahony, Erica, Pang, Dong, Pang, Dong, Randhawa, Gurch   +7 more
core   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Growing older, staying well: mental health care for older Australians [PDF]

This study finds that more support, services and education are needed to appropriately care for Australia\u27s ageing population.Recommendations:Stronger lobbying and advocacy giving the needs of older people living with mental illness more prominence ...

core