Results 111 to 120 of about 1,367,738 (299)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Assessing morbidity in the paediatric community

Revista de Saúde Pública, 1999
INTRODUCTION: Morbidity information is easily available from medical records but its scope is limited to the population attended by the health services.
Escuder Maria Mercedes L, Silva Nilza N da, Pereira Júlio CR, Puccini Rosana F, Herrman Anneliese A   +4 more
doaj  

Shortcomings of services for persons with severe and persistent mental health challenges: a qualitative study of service users and family carers

Frontiers in Psychiatry
IntroductionThe opinions of service users and carers are crucial to identifying ways to innovate and implement system change. This study aims to explore the views and experiences of service users and carerson the services they have used for their mental ...
Anton Isaacs, Caroline Lambert, Caroline Lambert, Sharon Lawn, Sharon Lawn, Anna Dyer   +5 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Identificando necessidades e possíveis soluções: com a palavra, pessoas idosas na Atenção Primária à Saúde

Saúde em Debate
RESUMO O objetivo deste artigo é compreender a percepção de pessoas idosas sobre a atenção à saúde promovida por profissionais da Estratégia Saúde da Família e do Núcleo de Apoio à Saúde da Família para o enfrentamento de suas necessidades.
Rafael Rodolfo Tomaz de Lima, Marcelo Viana da Costa, Rosana Lúcia Alves de Vilar, Janete Lima de Castro, Kenio Costa de Lima   +4 more
doaj   +1 more source

Hi ho silver lining? What firms need to think about as New Zealand ages [PDF]

This report argues that the ageing New Zealand population will see fewer productive workers in proportion to the number of retirees which will drive up wages, and that firms need to prepare.
John Ballingall, John Stephenson, Kirdan Lees   +2 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Working in decentralised service systems: challenges and choices for the Australian aid program [PDF]

The report examined Australia’s support for service systems in decentralised contexts - the evaluation focussed on the health, education and infrastructure (water, sanitation and roads) sectors.
Helen Cheney, Juliet Willetts, Karen Ovington, Keren Winterford   +3 more
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Support services for informal caregivers of community- dwelling frail elderly: a systematic review

International Journal of Integrated Care, 2012
Maja Lopez Hartmann, Johan Wens, Veronique Verhoeven, Roy Remmen   +3 more
doaj   +3 more sources