Results 41 to 50 of about 77,141,905 (265)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

Health Research Board Annual Report 2022 [part 1] [PDF]

, 2023
2022 was another highly successful year for the Health Research Board (HRB). It also marked the first full calendar year of operation of our strategy for 2021–2025, Health research – making an impact, which sets out how we will advance health research ...
Health Research Board
core  

Blockchain protocols in clinical trials: Transparency and traceability of consent [version 3; referees: 1 approved, 2 approved with reservations, 1 not approved]

F1000Research, 2017
Clinical trial consent for protocols and their revisions should be transparent for patients and traceable for stakeholders. Our goal is to implement a process allowing the collection of patients’ informed consent, which is bound to protocol revisions ...
Mehdi Benchoufi, Raphael Porcher, Philippe Ravaud   +2 more
doaj   +1 more source

Parents of Youth With Cancer Report on Their Psychosocial Care: iSTEPPP Survey Finds Alignment and Gaps With Standards

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Standards for Psychosocial Care for Children with Cancer and Their Families guide the provision of comprehensive psychosocial care. Parallel to research characterizing implementation of the Standards from the perspective of providers, this study examines implementation of the Standards from the perspective of parents of youth ...
Emily M. Pariseau, Kimberly Buff, Michele A. Scialla, Kimberly S. Canter, Lori Wiener, Victoria Sardi‐Brown, Julia B. Tager, Kamyar Arasteh, Anne E. Kazak   +8 more
wiley   +1 more source

Primary health care assessment in Brazil: conception and methodology of the 2024 National Basic Health Unit Census

Cadernos de Saúde Pública
Primary health care (PHC) is the basis of the Brazilian Unified National Health System (SUS). After a discontinuity in PHC evaluation policies, the Ministry of Health, with the support of the PHC Research Network of the Brazilian Association of Public ...
Aylene Bousquat, Ligia Giovanella, Rosana Aquino, Ana Luiza Queiroz Vilasbôas, Elaine Thumé, Elaine Tomasi, Maria Helena Magalhães de Mendonça, Alaneir de Fátima da Silva, Patty Fidelis de Almeida, Paulo Henrique dos Santos Mota, Carlos Pilz, Elisandréa Sguario Kemper, Dirceu Klitzke, Gabriela da Silva Formoso, Bruna Venturin, Luiz Augusto Facchini   +15 more
doaj   +2 more sources

Improving data transparency in clinical trials using blockchain smart contracts [version 1; referees: 3 approved]

F1000Research, 2016
The scientific credibility of findings from clinical trials can be undermined by a range of problems including missing data, endpoint switching, data dredging, and selective publication. Together, these issues have contributed to systematically distorted
Timothy Nugent, David Upton, Mihai Cimpoesu   +2 more
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

How blockchain-timestamped protocols could improve the trustworthiness of medical science [version 1; referees: 2 approved]

F1000Research, 2016
Trust in scientific research is diminished by evidence that data are being manipulated. Outcome switching, data dredging and selective publication are some of the problems that undermine the integrity of published research.
Greg Irving, John Holden
doaj   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source

Towards a systems approach for chronic diseases, based on health state modeling [version 1; referees: 2 approved]

F1000Research, 2017
Rising pressure from chronic diseases means that we need to learn how to deal with challenges at a different level, including the use of systems approaches that better connect across fragments, such as disciplines, stakeholders, institutions, and ...
Michael Rebhan
doaj   +1 more source