Results 81 to 90 of about 888,949 (266)

Association between Internet addiction and mental health problems among Chinese adolescents in the post-COVID-19 pandemic era: a propensity score matching study

BMC Psychology
Background Improving adolescent mental health is a priority for public health, with Internet addiction (IA) being notably linked to these problems. In the post-pandemic era, increased screen time and social isolation persist, albeit in a more normalized ...
Yinmei Yang, Weijia Zhao, Xiaoman Wu, Clifford Silver Tarimo, Haiyang Feng, Yongji Gao, Jian Wu   +6 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Social Media and Men’s Health: Separating Science from Speculation in Andrology

Basic and Clinical Andrology
Background Social media has rapidly evolved into a primary source of health-related information. For men with concerns regarding their sexual health or fertility, consulting the internet is often felt to be an accessible first-step in exploring their ...
Michael George, Vaibhav Modgil, Ian Pearce, Theodora Stasinou   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

COVID-19 and older people’s wellbeing in northern KwaZulu-Natal – the importance of relationships [version 5; peer review: 2 approved, 1 not approved]

Wellcome Open Research
Background The COVID-19 pandemic and the non-pharmacological prevention methods have affected the wellbeing of older people. In this paper we focus on the wellbeing, and vulnerability, of older people in rural northern KwaZulu-Natal, South Africa during ...
Nothando Ngwenya, Anita Edwards, Thabang Manyaapelo, Samukelisiwe Nxumalo, Nondumiso Mpanza, Ntombizonke Gumede, Zama Nxumalo, Janet Seeley   +7 more
doaj   +1 more source

Public Health and the Social Sciences [PDF]

Public Health Reports (1896-1970), 1957
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Developing a stakeholder-informed social responsibility model for translational science.

PLoS ONE
Innovation in biomedical research has increased markedly over the last few decades. However, clinical, therapeutic, and public health advances have often not yielded expected improvements in health outcomes nor reduced disparities.
Elise M R Smith, Georgia Loutrianakis, Kimberly Beatty, Krista Bohn, Kathryn A Cunningham, Sharon Croisant, Jeffrey S Farroni, Micheal Gienger, Dominique Guinn, Jometra Hawkins-Sneed, Sondip Mathur, Victoria McNamara, Marnina Miller, Stephen Molldrem, Kimberly Pounds, Vishnu Subrahmanyam, Emma Tumilty, Grace A Loudd   +17 more
doaj   +1 more source

Digital mental health interventions for adolescents and young people (10–24 years) in Africa: A protocol for a systematic review of mental health outcomes, engagement, and equity considerations [version 1; peer review: 2 approved]

Wellcome Open Research
Background Adolescents and young people (AYP) aged 10–24 years in Africa experience a high burden of mental health disorders but face significant barriers to accessing care, including a severe shortage of mental health professionals, stigma, and limited ...
Aggrey Gisiora Mokaya, Nothando Ngwenya, Syethemba Nkosi, Nondumiso Michelle Dlamini, Thandeka Smith, Mpilonhle Thembinkosi Nzuza, Alan Stein, Grace Nduku Wambua, Xanthe Hunt   +8 more
doaj   +1 more source