Results 111 to 120 of about 12,640,325 (235)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Culture Change and Quality of Care Among High Medicaid Nursing Homes: Does Earlier Implementation Matter?

Journal of Long-Term Care
Context: High Medicaid nursing homes are under-resourced and associated with lower resident quality of care. Culture change initiatives, a movement to transition nursing homes to more home-like environments, are a potential process to improve residents’
Latarsha Chisholm, Akbar Ghias, Rohit Pradhan, Justin Lord, Ganisher Davlyatov, Robert Weech-Madonado   +5 more
doaj   +1 more source

Change in the Healthiness of Foods Sold in an Australian Supermarket Chain Following Implementation of a Shelf Tag Intervention Based on the Health Star Rating System. [PDF]

Nutrients, 2022
Cameron AJ, Brown A, Orellana L, Marshall J, Charlton E, Ngan WW, Ananthapavan J, Isaacs J, Blake M, Sacks G.   +9 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Enhancing iRAP Star Ratings in Brunei

Journal of Road Safety
Injuries from crashes on the road remain a global public health crisis. The International Road Assessment Programme (iRAP) addresses the safer roads pillar of the Safe System approach to road safety through a standardised star rating system. In line with
Shane Turner, Olivia Heer, Lewis Martin, Marc Robson   +3 more
doaj   +1 more source

Balanced Hybrid Nutrient Density Score Compared to Nutri-Score and Health Star Rating Using Receiver Operating Characteristic Curve Analyses. [PDF]

Front Nutr, 2022
Drewnowski A, Gonzalez TD, Rehm CD.
europepmc   +1 more source

Rating of state environment impact assessment authorities

, 2022
The star-rating of SEIAAs is aimed at incentivizing the states based on “the efficiency and timelines in the grant of environmental clearance.” The SEIAAs that take longer to grant environmental clearance to companies or seek essential details about the ...
Singh, Govind
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source