Results 91 to 100 of about 8,062,995 (308)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Comparison of health-related quality of life measures in chronic obstructive pulmonary disease

Health and Quality of Life Outcomes, 2011
Background The aims of this study were: (1) to compare the discriminative ability of a disease-specific instrument, the St. George's Respiratory Questionnaire (SGRQ) to generic instruments (i.e., EQ-5D and SF-36); and (2), to evaluate the strength of ...
Lee Todd A, Yang Yoojung, Pickard A Simon   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Dynamics of Race, Culture and Key Indicators of Health in the Nation's 100 Largest Cities and Their Suburbs [PDF]

, 2003
Profiles the 2000 status of, and changes since 1990, in rates of health and health-related measures to identify patterns in race/ethnicity, foreign-born status, language use, poverty, income, low birth weight, teen births, prenatal care, and ...
Dennis P. Andrulis, Hailey M. Reid, Lisa M. Duchon   +2 more
core  

The physical and mental health of acute psychiatric ward staff, and its relationship to experience of physical violence [PDF]

, 2018
To evaluate and describe the physical and mental health of staff on acute psychiatric wards and examine whether violence exposure is linked with health status. We undertook a cross-sectional survey with 564 nursing staff and healthcare assistants from 31
Aiken, Arnetz, Bogaert, Bonevski, Bowers, Bowers, Bowers, Campbell, Das-Munshi, Edward, Edwards, England, England, Field, Flannery, Flannery, Foster, Gajwani, Gerberich, Hall, Hanrahan, Harris, Health and Safety Executive, Health And Social Care Information Centre, Jalil, Jenkinson, Johnson, Johnson, Kapur, Kirkbride, Leeuwen, Maben, Martin, McCarthy, Memon, Morgan, Needham, Nijman, Pekurinen, Reininghaus, Renwick, Renwick, Richards, Robertson, Salyers, Sheikh, Singh, Ware, Ware, Whittington, Winkelmann-Gleed, Wood   +51 more
core   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Damage evaluation and resistance enhancement technologies for highway tunnels under high-power fire conditions

Case Studies in Thermal Engineering
The operation of highway tunnels involves numerous complex challenges, which become particularly pronounced during extreme disasters such as fires. This study takes the Qinling Tiantai Mountain Highway Tunnel as the engineering background and focuses on ...
Yufeng Sun, Miaohang Kang, Mingxia Zhang, Fei Ye, Xiaolin Weng, Chaodi Zhu, Dengfei Xu   +6 more
doaj   +1 more source

The impact of health on poverty: Evidence from the South African integrated family survey [PDF]

This paper examines the impact of health status on poverty status, accounting for the endogeneity of health status. Using exogenous measures of health status from the South African Integrated Health Survey, we instrument for health status while allowing ...
Malcolm Keswell, Susan Godlonton
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source