Results 151 to 160 of about 1,506,645 (358)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Big data reveals deep associations in physical examination indicators and can help predict overall underlying health status

, 2019
Haixin Wang, Ping Shuai, Yanhui Deng, Jiyun Yang, Shanshan Zhang, Yi Yin, Lin Wang, Dongyu Li, Yong Tao, Yuping Liu, Lulin Huang   +10 more
openalex   +1 more source

Assessment of cognitive status of employees as indicator of early health disorders

, 2020
E. P. Kontorovich, Yu. Yu. Gorblyansky, О. P. Ponamareva   +2 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Association between socio-economic status and health of older adults in rural Bangladesh and India: a comparative cross-sectional study [PDF]

Inequalities in health are noticeable among older people in many developing countries, driven by poor social protection systems and low socio-economic status (SES).
Khan, Hafiz T.A., Kowal, Paul, Rahman, Mijanur   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A Robust Wind Turbine Component Health Status Indicator [PDF]

Roberto Lázaro, Julio J. Melero, Nurseda Y. Yürüşen   +2 more
openalex   +1 more source

Retirement Research Using the Health and Retirement Survey [PDF]

This paper highlights unanswered research questions in the economics of retirement, and shows how these issues can be addressed using the new Health and Retirement Survey (HRS). Unique features of the survey are described including administrative records
Alan L. Gustman, Olivia S. Mitchell, Thomas L. Steinmeier   +2 more
core  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Dificultades en la interpretación de los resultados de la investigación biomédica relacionada con el manejo de pacientes con enfermedades crónicas no transmisibles

Revista Peruana de Medicina Experimental y Salud Pública
El incremento progresivo en las prevalencias de las enfermedades crónicas no transmisibles (ECNT), ha generado la necesidad de cambiar los paradigmas en la interpretación de la investigación que se genera con relación a estrategias terapéuticas y de ...
Gordon H Guyatt, Germán Málaga
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