Results 161 to 170 of about 1,624,025 (308)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A natimortalidade como indicador de saúde perinatal

Cadernos de Saúde Pública
Os autores realizaram uma revisão bibliográfica do tema natimortalidade, abordando seus aspectos conceituais e epidemiológicos, destacando principalmente a sua relevância com indicador de saúde perinatal.
Dino Roberto Soares De Lorenzi, Ana Cristina d'Andretta Tanaka, Mari Clarisse Bozzetti, Flávio Elias Ribas, Leonardo Weissheimer   +4 more
doaj   +2 more sources

Pacto pela saúde no Brasil: uma análise descritiva da progressão dos indicadores de saúde bucal

Revista de Odontologia da UNESP
INTRODUÇÃO: Desde a implantação do Sistema Único de Saúde (SUS) no Brasil, inúmeras e constantes são as tentativas de ampliação de mecanismos que levem à otimização dos serviços públicos de saúde.
Danielle Bordin, Cristina Berger Fadel
doaj  

Income inequality and health status: role of institutions quality [PDF]

This paper investigates the relationships between health indicators, institutional variables and income inequality. In the economic literature, the impact of income distribution on health status is largely studied.
Alassane Drabo
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Mudanças em indicadores de saúde infantil em um município com agentes comunitários: o caso de Itapirapuã Paulista, Vale do Ribeira, São Paulo, Brasil

Cadernos de Saúde Pública
Doze agentes comunitários de saúde (ACS) foram treinados para diagnosticar e iniciar tratamento de diarréia e infeção respiratória no domicílio, monitorar crescimento, incentivar imunização básica e orientar a introdução de alimentos à dieta entre ...
Juraci A. Cesar, Marcelo A. Cavaleti, Ricardo S. Holthausen, Luis Gustavo S. de Lima   +3 more
doaj  

Association between socio-economic status and health of older adults in rural Bangladesh and India: a comparative cross-sectional study [PDF]

Inequalities in health are noticeable among older people in many developing countries, driven by poor social protection systems and low socio-economic status (SES).
Khan, Hafiz T.A., Kowal, Paul, Rahman, Mijanur   +2 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source