Results 111 to 120 of about 849,913 (310)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
This brochure provides information on surveys supported by the Centers for Disease Control and Prevention\u2019s (CDC) Office on Smoking and Health. CDC also analyzes data collected using surveys from other federal agencies, such as the National Health ...
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Herpes zoster vaccination: Primary care provider knowledge, attitudes, and practices
Human Vaccines & ImmunotherapeuticsPrimary care providers (PCPs) play a key role in vaccine recommendations and uptake, but limited information exists about PCP knowledge, attitudes, and practices regarding herpes zoster (HZ) vaccination. Clinical trials have shown that recombinant zoster
Nikita Stempniewicz +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The National Center for Health Statistics\u2019 2015 and 2016 research and development surveys
Objective: This report provides a general description of the background and operation of the first two rounds of the Research and Development Survey (RANDS), a series of cross-sectional surveys from probability-sampled commercial survey panels.
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An overview of National Health Measurement Surveys [PDF]
, 2003 © Commonwealth of AustraliaThe purpose of this paper is to provide a brief overview of a number of national health surveys that incorporate physical and biochemical measures, and to identify their features and the differences in approaches taken by ...
Hetzel, Diana M. S.
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Environmental Research LettersIt is anticipated that climate change and climate variability will threaten food and nutrition security through multiple pathways, yet evidence on its impact on minimum dietary diversity for women (MDD-W), especially in low- and middle- income countries (
B Carducci +9 more
doaj +1 more source