Results 241 to 250 of about 849,913 (310)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Predictors and prevalence of self-reported sexually transmitted infections among pregnant women in East Africa: evidenced by demographic and health surveys. [PDF]

BMC Infect Dis
Mankelkl G, Abdu SM, Assefa EM, Kassaw AB, Abebe G, Belete M, Tareke AA, Alem A, Bihonegn MD, Abdu H, Abebe MS, Geto Z, Gedefie A, Kinfe B.   +13 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Predictors and barriers to minimally adequate treatment among treated individuals with mental disorders: results from the World Mental Health Surveys. [PDF]

Int J Ment Health Syst
Pozuelo JR, Vigo DV, Kazdin AE, Harris MG, Stein DJ, Viana MC, Hwang I, Kessler TL, Manoukian SM, Sampson NA, Aguilar-Gaxiola S, Alonso J, Andrade LH, Ayinde OO, Bruffaerts R, Bunting B, Caldas-de-Almeida JM, Chardoul S, de Girolamo G, Domenech C, Gureje O, Karam EG, Kiejna A, Kovess-Masfety V, Medina-Mora ME, Moskalewicz J, Navarro-Mateu F, Nishi D, Piazza M, Posada-Villa J, Scott KM, Ten Have M, Torres Y, Vladescu C, Kessler RC, World Mental Health Survey collaborators.   +35 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Discharge time from healthcare facilities after birth in Tanzania : a secondary analysis of demographic and health surveys from 2015 to 16 and 2022. [PDF]

BMC Health Serv Res
Semaan A, Apers L, Kikula A, van den Akker T, Pembe AB, Beňová L, Housseine N.   +6 more
europepmc   +1 more source

Inequalities in complete pneumococcal vaccination among Peruvian children before and after the COVID-19 pandemic: An evaluation using demographic and health surveys from 2018 to 2023. [PDF]

Epidemiol Infect
Gonzales BE, Ochoa TJ, van der Sande MAB.   +2 more
europepmc   +1 more source

Trends and geographic patterns of overweight and obesity among Tanzanian adults: Evidence from the 2010-2022 Demographic and Health Surveys. [PDF]

PLoS One
Lutambi AM, Mwing'a GP, Emidi B.
europepmc   +1 more source

MUNICIPAL HEALTH DEPARTMENTS IN SURVEY

American Journal of Public Health, 1916
openaire   +3 more sources