Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Commercial milk formula feeding among children under two years in Nepal: Trends and determinants from four Nepal Demographic and Health Surveys (2006-2022). [PDF]
PLoS OneSingh BK, Bista S, Yogesh S, Khanal V.
europepmc +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Implementing a machine learning model to predict continuation of contraception among women aged 15-49: secondary data analysis of the last 4 demographic and health surveys in the majority of West African countries. [PDF]
Reprod HealthMagassouba AS +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Trends and Determinants of Skilled Birth Attendants' use among Women of Reproductive Age in Tanzania: Evidence from the 2004/05-2022 Demographic Health Surveys. [PDF]
PLoS OneTibenderana JR +9 more
europepmc +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Use of Mobile Forms in Low-Resource Areas for Population Health Surveys: Interview and Field Test Study. [PDF]
JMIRx MedDavis A, Chen A, Chen M, Davis J.
europepmc +1 more source
Trends in hypertension prevalence, control, and antihypertensive use in England from 2003 to 2021: insights from annual, nationwide Health Surveys for England. [PDF]
BMJ MedGraham C +7 more
europepmc +1 more source