Results 151 to 160 of about 5,668,863 (316)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Other title: Two Thousand Eight Behavioral Risk Factor Surveillance System
, 2009 application/pdf; Report Preparation: Ghazala Perveen [and] Pratik Pandya.; "Funding for data collection of Anxiety and Depression module using the 2008 Behavioral Risk Factor Survey was provided by cooperative agreement # 1U58DP001968-01 from the Centers
Kansas. Bureau of Health Promotion.
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Other title: Two Thousand Ten Behavioral Risk Factor Surveillance System
, 2012 application/pdf; Report Preparation: Pratik Pandya. Report Supervision: Ghazala Perveen.; "Funding for data collection of Anxiety and Depression module using the 2010 Behavioral Risk Factor Survey was provided by cooperative agreement # U58DP001968 ...
Kansas. Bureau of Health Promotion.
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Acute viral myositis complicated by rhabdomyolysis: a sole manifestation of COVID-19 infection
Journal of Community Hospital Internal Medicine Perspectives, 2021 Mohsin Sheraz Mughal +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Health System Integration and Prior Authorization in Medicare Advantage. [PDF]
Health Serv ResShin E.
europepmc +1 more source
Other title: Results from Two Thousand Five Kansas Behavioral Risk Factor Surveillance System
, 2006 application/pdf; Report Preparation: Catima Potter [and] Ghazala Perveen.; "Funding for this report was provided by the Bureau of Air and Radiation (KDHE) and Council of State and Territorial Epidemiologist (CSTE).Y."; "August 2006."; Includes ...
Kansas. Office of Health Promotion.
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