Results 181 to 190 of about 5,668,863 (316)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

"Beyond the Crisis: Forging a Climate-Resilient Health System for Bangladesh". [PDF]

Health Sci Rep
Mamun AA, Kayenat MSA.
europepmc   +1 more source

Health information system.

Einstein (Sao Paulo, Brazil), 2013
de Souza, Valéria Pinheiro, dos Santos, Oscar Fernando Pavão, Wolosker, Nelson   +2 more
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The role of community health workers in strengthening health system resilience in Somalia. [PDF]

Trop Med Health
Sudi LA, Abdullahi YB, Mohamed MD, Hassan AA, Ibrahim IO, Adan AM.   +5 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Melatonin prescribing characteristics and delirium outcomes: A health system database-based study. [PDF]

Gen Hosp Psychiatry
Lin M, Smith PJ, Zeng X, Xia K, Ye S, Nakamura ZM.   +5 more
europepmc   +1 more source

P748: Duplication of 12q24.11-q24.31 in a patient with Noonan-like features

Genetics in Medicine Open
Ludmila Francescatto, Benjamin Cocanougher, Kristen Deak, Catherine Rehder, Sarah Rapisardo, Areeg El-Gharbawy, Stefan Rentas   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rural-Urban Differences in Hypertension Prevalence and Control in a Large Regional Health System Cohort. [PDF]

J Clin Med
Tiruneh YM, McBride S, Song H, Decaro M, Rihan A, Byrd T, Baham A, Magnani JW, Bernstam EV, Berry JD.   +9 more
europepmc   +1 more source