Results 271 to 280 of about 41,645,780 (407)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

The Global Impact of Sepsis: Epidemiology, Recognition, Management, and Health System Challenges. [PDF]

Epidemiologia (Basel)
La Via L, Ferlito S, Di Modica MS, Marino A, Nunnari G, Cacopardo B, Lechien JR, Lentini M, Lavalle S, Botto GC, Buscema P, Gruppuso L, Maniaci A.   +12 more
europepmc   +1 more source

State Health Department Perceived Utility of and Satisfaction with ArboNET, the U.S. National Arboviral Surveillance System

, 2012
Nicole P. Lindsey, Jennifer A. Brown, Lon Kightlinger, Lauren Rosenberg, Marc Fischer, The ArboNET Evaluation Working Group   +5 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Nurse-Surgeons' Experiences Working in the Australian Public Health System: A Qualitative Exploration. [PDF]

J Nurs Manag
Grota T, Burston A, Betihavas V, Jacob E.   +3 more
europepmc   +1 more source

The Brazilian health system: history, advances, and challenges.

The Lancet, 2011
J. Paim, C. Travassos, C. Almeida, L. Bahia, J. Macinko   +4 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

The Vicious Impact of Antimicrobial Resistance on Global Public Health Security and the Role of Healthcare Systems and Policy in Combating AMR [PDF]

Maleka Sultana, Noman Perves, Nasir Uddin, Mahbub-E-Elahi Chowdhury, Muhamad Amin   +4 more
openalex   +1 more source

The medical expenses in diabetes outpatient: The health-care systems affect accounting and hospital management, and issues in diabetes treatment in Japan

, 2020
Oogi Inada, Akari Inada
openalex   +2 more sources

Development of the Learning Health System Researcher Core Competencies.

Health Services Research, 2018
C. Forrest, F. Chesley, Michelle L Tregear, Kamila B. Mistry   +3 more
semanticscholar   +1 more source