Results 41 to 50 of about 28,445,610 (266)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

DRAFT Report:Community Systems Strengthening Toward a Research Agenda [PDF]

, 2014
Communities have a long history of acting to preserve and promote the health of their members. Public health researchers, programmers, and funders are increasingly recognizing that community involvement is essential to improving health, especially among ...
Ayala, George, Chong, Susan, Greenall, Matthew, Arreola, Sonya, Mallouris, Christoforos   +4 more
core  

How can we evaluate the cost-effectiveness of health system strengthening? A typology and illustrations. [PDF]

, 2018
Health interventions often depend on a complex system of human and capital infrastructure that is shared with other interventions, in the form of service delivery platforms, such as healthcare facilities, hospitals, or community services.
Verguet, S, Meacock, R, Culyer, Anthony, Chalkidou, K, Culyer, A., Smith, P.C., Thomas, R., Morton, A., Meacock, R., Vassall, A., Over, Mead, Over, M, Chalkidou, Kalipso, Levin, Carol, Morton, Alec, Verguet, Stephan, Vassall, Anna, Chalkidou, K., Vassall, A, Verguet, S., Smith, P. C., Levin, C, Hauck, K., Hauck, Katharina, Verguet, Stephane, Smith, Peter, Hauck, K, Culyer, A, Vassal, Anna, Thomas, R, Smith, PC, Thomas, Ranjeeta, Morton, A, Chi, Y. Ling, Levin, C., Chi, Y-Ling, Over, M., Meacock, Rachel   +37 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Health system recovery in Northwest Syria–challenges and operationalization

Humanities & Social Sciences Communications, 2023
The demonstrations in Syria in 2011 became an uncompromising conflict that divided the country into three main areas of control: governmental areas, northeast Syria, and Northwest Syria.
Orwa Al-Abdulla, Abdulkarim Ekzayez, Agneta Kallström, Camilo Valderrama, Maher Alaref, Jussi Kauhanen   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Lithuania: health system review [PDF]

, 2013
150 p.This analysis of the Lithuanian health system reviews the developmentsin organization and governance, health financing, health care provision,health reforms and health system performance since 2000.
Janoniene, Raimonda, van Ginneken, Ewout, Murauskiene, Liubove, European Observatory on Health Systems and Policies, Veniute, Marija, Karanikolos, Marina, World Health Organization. Regional Office for Europe   +6 more
core   +1 more source

Health information management systems and practices in conflict-affected settings: the case of northwest Syria

Globalization and Health
Background In conflict settings, as it is the case in Syria, it is crucial to enhance health information management to facilitate an effective and sustainable approach to strengthening health systems in such contexts.
Reem Ladadwa, Mahmoud Hariri, Muhammed Mansur Alatras, Yasir Elferruh, Abdulhakim Ramadan, Mahmoud Dowah, Yahya Mohammad Bawaneh, Wassel Aljerk, Preeti Patel, Abdulkarim Ekzayez, Nassim El Achi   +10 more
doaj   +1 more source

Performance of novel digital real-time PCR for detection of SARS-CoV-2, respiratory syncytial viruses, and influenza viruses in Ghana

Microbiology Spectrum
Digital PCR (dPCR) systems offer high sensitivity and reproducibility without requiring external control standards. However, their performance against real-time reverse transcription-PCR (rRT-PCR) for detecting respiratory viruses remains unexplored in ...
Michael Owusu, Bernard Nkrumah, Godfred Acheampong, Stephen Opoku Afriyie, Ebenezer Kojo Addae, Richard Larbi, Richard Owusu Ansah, Chrysantus Kubio, Farouk Saeed, Nana Kwame Ayisi-Boateng, Eric Darko, Jacob Amonoo-Neizer, Abena Gyawu Owusu-Ansah, Frederick Ayensu, Peter Kojo Brenya, Veronica Bannor, Pawan Angra, Danielle Thompson Barradas   +17 more
doaj   +1 more source