Results 51 to 60 of about 28,445,610 (266)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Health Systems Analysis for Better Health System Strengthening

, 2011
Health system strengthening and reform are often necessary actions to achieve better outcomes. The World Bank's 2007 strategy for health, nutrition, and population emphasizes the importance of health system
Berman, Peter, Bitran, Ricardo
core   +1 more source

Implementing ideal health policy in a fragile health system: the example of expanding the use of malaria rapid diagnostic tests in mainland Tanzania. [PDF]

, 2011
Malaria confirmation before treatment provides an opportunity for improving the quality of malaria case management in endemic regions. However, increased coverage of this strategy is facing many organizational, logistical and technical challenges that ...
Jan Jacobs, de Bethune, Xavier, Masanja Irene M, Jacobs Jan, Irene M Masanja, Masanja, Irene M, Xavier de Bethune, de Bethune Xavier, Jacobs, Jan   +8 more
core   +1 more source

An analysis of humanitarian and health aid harmonisation over a decade (2011–2019) of the Syrian conflict

BMJ Global Health
Introduction Aid harmonisation is a key component of donor efforts to make aid more effective by improving coordination and simplifying and sharing information to avoid duplication. This study evaluates the harmonisation of health and humanitarian aid in
Aula Abbara, Kristen Meagher, Preeti Patel, Abdulkarim Ekzayez, Nassim El Achi, Munzer Alkhalil, Maher Alaref, Rim Turkmani, Zedoun Al Zoubi   +8 more
doaj   +1 more source

Management Matters: A Leverage Point for Health Systems Strengthening in Global Health [PDF]

International Journal of Health Policy and Management, 2015
Despite a renewed focus in the field of global health on strengthening health systems, inadequate attention has been directed to a key ingredient of high-performing health systems: management.
Elizabeth H. Bradley , Lauren A. Taylor, Carlos J. Cuellar   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Immunisation Rates of Medical Students at a Tropical Queensland University

Tropical Medicine and Infectious Disease, 2018
Although medical students are at risk of contracting and transmitting communicable diseases, previous studies have demonstrated sub-optimal medical student immunity.
Erin Fergus, Richard Speare, Clare Heal
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Meningococcal vaccine introduction in Mali through mass campaigns and its impact on the health system. [PDF]

, 2014
OBJECTIVE: To evaluate the impact of the meningococcal A (MenA) vaccine introduction in Mali through mass campaigns on the routine immunization program and the wider health system.
Burchett, Helen Elizabeth Denise, Konate, Mamadou, Griffiths, Ulla Kou, Mounier-Jack, Sandra, Diarra, Kassibo Sira   +4 more
core   +1 more source