Results 171 to 180 of about 37,883,283 (358)
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
WHO's Fooling Who? The World Health Organization's Problematic Ranking of Health Care Systems [PDF]
The World Health Report 2000, prepared by the World Health Organization, presented performance rankings of 191 nations' health care systems. These rankings have been widely cited in public debates about health care, particularly by those interested in ...
Glen Whitman
core
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Biofeedback systems for stress reduction: Towards a Bright Future for a Revitalized Field [PDF]
Stress has recently been baptized as the black death of the 21st century, which illustrates its threat to current health standards. This article proposes biofeedback systems as a means to reduce stress.
Broek, Egon L. van den +1 more
core +2 more sources
Diversity and complexity in neural organoids
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Corn Cropping Systems to Improve Economic and Environmental Health [PDF]
In 2017, UVM Extension’s Northwest Crops & Soils Program continued a multi-year trial at Borderview Research Farm in Alburgh, VT to assess the impact of corn cropping systems on overall health and productivity of the crop and soil.
Cubins, Julija +4 more
core +1 more source
Contribution of primary care to health systems and health.
B. Starfield, Leiyu Shi, J. Macinko
semanticscholar +1 more source
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Corn Cropping Systems to Improve Economic and Environmental Health [PDF]
In 2015, UVM Extension’s Northwest Crops & Soils Program continued a multi-year trial at Borderview Research Farm in Alburgh, VT to assess the impact of corn cropping systems on overall health and productivity of the crop and soil.
Calderwood, Lily +6 more
core +1 more source

