Results 171 to 180 of about 37,883,283 (358)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

WHO's Fooling Who? The World Health Organization's Problematic Ranking of Health Care Systems [PDF]

open access: yes, 2008
The World Health Report 2000, prepared by the World Health Organization, presented performance rankings of 191 nations' health care systems. These rankings have been widely cited in public debates about health care, particularly by those interested in ...
Glen Whitman
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Biofeedback systems for stress reduction: Towards a Bright Future for a Revitalized Field [PDF]

open access: yes, 2012
Stress has recently been baptized as the black death of the 21st century, which illustrates its threat to current health standards. This article proposes biofeedback systems as a means to reduce stress.
Broek, Egon L. van den   +1 more
core   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Corn Cropping Systems to Improve Economic and Environmental Health [PDF]

open access: yes, 2017
In 2017, UVM Extension’s Northwest Crops & Soils Program continued a multi-year trial at Borderview Research Farm in Alburgh, VT to assess the impact of corn cropping systems on overall health and productivity of the crop and soil.
Cubins, Julija   +4 more
core   +1 more source

Contribution of primary care to health systems and health.

open access: yesMilbank Quarterly, 2005
B. Starfield, Leiyu Shi, J. Macinko
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Corn Cropping Systems to Improve Economic and Environmental Health [PDF]

open access: yes, 2015
In 2015, UVM Extension’s Northwest Crops & Soils Program continued a multi-year trial at Borderview Research Farm in Alburgh, VT to assess the impact of corn cropping systems on overall health and productivity of the crop and soil.
Calderwood, Lily   +6 more
core   +1 more source

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