Results 161 to 170 of about 37,883,283 (358)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Teaching Population Health: Innovations in the integration of the healthcare and public health systems [PDF]
, 2018 Population health is a critical concept in healthcare delivery today. Many healthcare administrators are struggling to adapt their organization from fee-for-service to value delivery.
Carmalt, Julie H. +3 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Challenges of Implementing Telemedicine Technology: A systematized Review
International Journal of Preventive MedicineBackground: Today, the technologies in the world are rapidly evolving, and global infrastructure of information is spreading rapidly. The health system of different countries is facing a variety of challenges in order to apply telemedicine services.
Marziye Hadian +5 more
doaj +1 more source
Explaining Health Reform: Building Enrollment Systems That Meet the Expectations of the Affordable Care Act [PDF]
, 2010 Highlights the enrollment system features needed to meet reform provisions for expanding health insurance coverage, examines states' current systems, and offers guidance on developing modernized, ACA-ready systems, including simplifying program ...
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
How health systems in sub-Saharan Africa can benefit from tuberculosis and other infectious disease programmes. [PDF]
, 2009 Weak and dysfunctional health systems in low-income countries, particularly in sub-Saharan Africa, are recognised as major obstacles to attaining the health-related Millennium Development Goals by 2015.
Enarson, D A +4 more
core +1 more source