Results 241 to 250 of about 6,736,762 (309)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Reframing Clinical Research in Latin America: Implications of Underrepresentation for Health Systems and Global Evidence. [PDF]

Cureus
Zavaleta-Monestel E, Martínez-Vargas E, Mora-Jiménez J, Arguedas-Chacón S.   +3 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Epidemiology of ICU Readmissions Across Ten Health Systems. [PDF]

Crit Care Explor
Amagai S, Chaudhari V, Chhikara K, Ingraham NE, Hochberg CH, Barker AK, Mao C, Ortiz AC, Weissman GE, Schmid BE, Schwinne M, Bhavani SV, Guleria S, Liao Z, Markov N, Lyons PG, Park-Egan B, Parker WF, Luo Y, Rojas JC, Gao CA, Common Longitudinal ICU data Format (CLIF) Consortium.   +21 more
europepmc   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

How floods impact health systems: a scoping review of Australian research. [PDF]

BMJ Open
Dorfer N, Bailie J, Ahern C, McNaught R, Scott K, Matthews V, Morgan GG, Ekanayake K, Bailie R.   +8 more
europepmc   +1 more source

A systematic model for health systems to prevent and respond to health emergencies in the workplace. [PDF]

BMC Health Serv Res
Farshad AA, Yarmohammadi S, Motalebi Gh M, Hassanzadeh-Rangi N, Faghihi M, Ezati E, Khosravi Y.   +6 more
europepmc   +1 more source

Strengthening health systems through NTD integration: Key insights from a multi-country webinar. [PDF]

PLoS Negl Trop Dis
Rozendaal N, Bassabi-Alladji MA, Bishaw T, Omondi W, Tolotra AF, Batchiri SA, Nshimiyimana L, Gnossike P, Jones C, Mubangizi A, Rebollo M.   +10 more
europepmc   +1 more source

Visualizing the Maternal Health Journey for Learning Health Systems: Mixed Methods Combined Experience Approach. [PDF]

J Particip Med
Joseph AL, Oladimeji B, Monkman H, Minshall SR, Tan MC, Quintana Y.   +5 more
europepmc   +1 more source