Results 121 to 130 of about 205,504 (307)

Unveiling neonatal mortality inequities in Ghana: A geospatial and temporal analysis of regional disparities, healthcare accessibility, and institutional gaps to drive targeted interventions

Pediatrics and Neonatology
Background: Neonatal mortality remains a significant public health challenge in Ghana, with regional disparities and systemic inequities affecting progress toward achieving Sustainable Development Goal (SDG) 3.
Ahmed Farhan Abubakr, Chrysantus Kubio
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Impact of Plasma p‐tau181 on Cognition, Motor Phenotypes, and Disease Course in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Phosphorylated tau181 (p‐tau181), an Alzheimer's disease biomarker, was recently evaluated in amyotrophic lateral sclerosis (ALS). We investigated plasma p‐tau181 in 202 ALS/ALS‐FTD patients and 94 healthy controls, assessing cognitive performance, motor function, and longitudinal dynamics.
Elisabeth Kasper, Annaliis Lehto, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Vogt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Anja Schneider, Stefan Teipel, Johannes Prudlo, Andreas Hermann   +25 more
wiley   +1 more source

'It's about time'. Dissemination and evaluation of a global health systems strengthening roadmap for musculoskeletal health - insights and future directions. [PDF]

BMJ Glob Health, 2023
Briggs AM, Chua J, Cross M, Ahmad NM, Finucane L, Haq SA, Joshipura M, Kalla AA, March L, Moscogiuri F, Reis FJJ, Sarfraz S, Sharma S, Soriano ER, Slater H.   +14 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Digital health systems strengthening in Africa for rapid response to COVID-19. [PDF]

Front Health Serv, 2022
Rinke de Wit TF, Janssens W, Antwi M, Milimo E, Mutegi N, Marwa H, Ndili N, Owino W, Waiyaiya E, Garcia Rojas DC, Dolfing M, de Graaff A, Swanepoel R, van der Graaf MH, Mulder D, De Sanctis T, Kratule S, Koyuncu C, Rogo K, Gómez-Pérez GP, Spieker N.   +20 more
europepmc   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Keeping health facilities safe: one way of strengthening the interaction between disease-specific programmes and health systems.

, 2010
The debate on the interaction between disease-specific programmes and health system strengthening in the last few years has intensified as experts seek to tease out common ground and find solutions and synergies to bridge the divide.
Frank Chimbwandira, Van Damme, Wim, Zachariah, Rony, Wafaa M. El-Sadr, Tayler-Smith, Katie, Chimbwandira, Frank, Erik J. Schouten, Katie Tayler-Smith, Wim Van Damme, Anthony D. Harries, Harries, Anthony D, El-Sadr, Wafaa M, Schouten, Erik J, Rony Zachariah   +13 more
core   +1 more source

Prevalence of Missed Medication Doses and Outcomes of Hospitalized Patients Living with HIV in Uganda

Drug, Healthcare and Patient Safety
Mary Madalen Angut,1 Humphrey Atwijukiire,2 Brian Mushabe,3 Katusabe Shamim,4 Brenda Namanda,5 Charles Mondo,6 Emmanuel Seremba,7 Charles Kabugo,8 Joseph Baruch Baluku9 1Division of Nursing, Kiruddu National Referral Hospital, Kampala, Uganda ...
Angut MM, Atwijukiire H, Mushabe B, Shamim K, Namanda B, Mondo C, Seremba E, Kabugo C, Baluku JB   +8 more
doaj  

Upper Cervical Cord Area as a Biomarker of Conversion to Secondary Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study assessed whether upper cervical cord area (UCCA) measured on routine brain MRI can serve as a biomarker of conversion to SPMS. Methods This is a single‐center retrospective cohort study of RRMS patients with cross‐sectional and longitudinal analyses of clinical and MRI data. Future SPMS converters were matched by age, sex,
Nabil K. El Ayoubi, Sola Al Ghazal, Salem Hannoun, Medhat A. Siddik, Nour M. Najjar, Jim Dagher, Joseph Abboud, Myriam G. Semaan, Samia J. Khoury   +8 more
wiley   +1 more source