Results 91 to 100 of about 5,578,781 (262)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Editorial: Health Technologies and Innovations to Effectively Respond to the Covid-19 Pandemic

Frontiers in Digital Health, 2022
Pradeep Nair
doaj   +1 more source

Nurses’ Job Satisfaction Regarding the Use of Health Technology: A Survey Study

Jurnal Keperawatan Indonesia
The development of innovative health technology is continuously needed by health workers, including nurses in hospitals. Nurses need to adapt and are required to be able to use various current technological innovations.
Diah Arruum, Setyowati, Hanny Handiyani, Raldi Artono Koestoer   +3 more
doaj   +1 more source

International Medical Technology Diffusion [PDF]

Does medical technology originating in countries close to the technology frontier have a significant impact on health outcomes in countries distant from this frontier?
Andreas Savvides, Chris Papageorgiou, Marios Zachariadis   +2 more
core  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Complex Care Management Program Overview - Technology [PDF]

, 2013
This report provides an overview of technology based complex care management programs, including:Cook County Health and Hospitals System - Computer Assisted Quality of Life and Symptom Assessment of Complex PatientsUniversity of Missouri ...

core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Assessing health technology implementation during academic research and early-stage development: support tools for awareness and guidance: a review

Frontiers in Digital Health
For successful health technology innovation and implementation it is key to, in an early phase, understand the problem and whether a proposed innovation is the best way to solve the problem. This review performed an initial exploration of published tools
Meyke Roosink, Lisette van Gemert-Pijnen, Ruud Verdaasdonk, Saskia M. Kelders   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Corrigendum: Effectiveness and usability of the system for assessment and intervention of frailty for community-dwelling pre-frail older adults: A pilot study

Frontiers in Medicine, 2022
Ren Siang Tan, Eileen Fabia Goh, Di Wang, Robin Chung Leung Chan, Zhiwei Zeng, Audrey Yeo, Kalene Pek, Joanne Kua, Joanne Kua, Wei Chin Wong, Wei Chin Wong, Wei Chin Wong, Zhiqi Shen, Zhiqi Shen, Wee Shiong Lim, Wee Shiong Lim, Wee Shiong Lim   +16 more
doaj   +1 more source