Results 201 to 210 of about 22,551,970 (267)

Conflicts of interest as a barrier to the development of health technology assessment in Iran: a qualitative study. [PDF]

J Health Popul Nutr
Behzadifar M, Shahabi S, Bakhtiari A, Martini M, Behzadifar M.   +4 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Demonstrating transportability of real-world evidence: what do HTA bodies and health technology developers need? [PDF]

Int J Technol Assess Health Care
Jaksa AA, Adamson B, Szulkin R, Dehlendorff C, Hernlund E, Ayyar Gupta V, Hanisch M, Wang-Silvanto J, Facey KM.   +8 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Timing of health technology assessment in the United States: An evaluation of ICER reviews over 8 years. [PDF]

J Manag Care Spec Pharm
Wright AC, McKenna A, Herce-Hagiwara B, Agboola F.   +3 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

The European Union's Health Technology Assessment Regulation (EU-HTA R) Will Prosper Despite Major Setbacks. [PDF]

J Mark Access Health Policy
Toumi M, Soussi I, Falissard B, Simoens S, Jouini A, Postma M, Wasem J, Solà-Morales O, Boyer L, Dussart C, Borissov B, Bernardini R, Capri S, Espin J, Auquier P.   +14 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Benefit-risk assessment in the context of health technology assessment: concepts, methods and applications. [PDF]

Epidemiol Serv Saude
de Soarez PC, Suzumura EA, Bortoluzzi AFR, Nonato AC, Maia FHA, Domingues SM, Ascef BO, Jahn B, Siebert U.   +8 more
europepmc   +1 more source