(Healthy) Aging Patterns in Europe: A Multistate Health Transition Approach. [PDF]
J Popul Ageing, 2023 Solé-Auró A, Gumà J.
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Erratum: Navigating disrupted puberty: Development and evaluation of a mobile-health transition passport for Klinefelter syndrome. [PDF]
Front Endocrinol (Lausanne), 2023 Frontiers Production Office.
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Use of business planning methods to monitor global health budgets in Turkmenistan
Bulletin of the World Health Organization, 2000 After undergoing many changes, the financing of health care in countries of the former Soviet Union is now showing signs of maturing. Soon after the political transition in these countries, the development of insurance systems and fee-for-service payment
Tim Ensor, Bakhtigul Amannyazova
doaj
Zero malaria: a mirage or reality for populations of sub-Saharan Africa in health transition. [PDF]
Malar J, 2022 Sarpong E +9 more
europepmc +1 more source
Health and the Transition from Employment to Retirement [PDF]
The relationship between employment and retirement is changing dramatically. In contrast to an earlier pattern of relatively stable career employment leading to retirement around age 65, increasing numbers of men and women are leaving their major ...
Philippa J. Clarke, Victor W. Marshall
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Balancing Technology, Ethics, and Society: A Review of Artificial Intelligence in Embryo Selection
InformationThe introduction of artificial intelligence (AI) in embryo selection during in vitro fertilization presents distinct ethical and societal challenges compared to the general implementation of AI in healthcare.
Roberto Aufieri, Francesco Mastrocola
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source