Results 201 to 210 of about 13,430,401 (352)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Health transition of Thai migrant women in Japan: a preliminary cross-sectional study in a country with insufficient migrant health data. [PDF]

Arch Public Health
Kobori E, Maeda Y, Kamata K, Nozue M, Fukuda H, Miura H.   +5 more
europepmc   +1 more source

China's health transitions [PDF]

The Lancet, 2014
openaire   +1 more source

Restructuring and taxation in transition economies [PDF]

One challenge in transition economies has been to avoid being caught between overrapid restructuring (harmful to the private sector) and gradual change (can undermine robust private sector emergence).
Commander, Simon, Tolstopiatenko, Andrei
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Colonial transition as a major mediator of global health transition: lessons from the 2024 New Caledonia crisis. [PDF]

J Glob Health
Moury PH, Tromhae M, Cazorla C, Série M, Flahault A, Couadau E, Fleury C, Mangeas M, De Greslan T.   +8 more
europepmc   +1 more source

Does health Matter for Inequality in Transition Countries: The Case of Ukraine [PDF]

Significant deterioration in health and income inequality in Ukraine as well as in other CIS countries during the early transition motivated us to investigate the relationship between the two categories.
Elena Osinkina, Larysa Krasnikova, Tamara Podvysotskaya, Yuriy Podvysotskiy   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Health transition and eye care policy planning for people with diabetic retinopathy in south Asia. [PDF]

Lancet Reg Health Southeast Asia
Das T, Islam K, Dorji P, Narayanan R, Rani PK, Takkar B, Thapa R, Moin M, Piyasena PN, Sivaprasad S.   +9 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source