Results 131 to 140 of about 10,030,185 (350)

Optimal health insurance contract : can moral hazard increase indemnity ?. [PDF]

In this note, we generalize the results obtained by Barday and Lesur (2005) by considering a bivariated non separable utility function. We characterize optimal health insurance contracts.
Alary, David, Bien, Franck
core  

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Ignored and undervalued in public health: a systematic review of health state utility values associated with syphilis infection

Health and Quality of Life Outcomes
Background Syphilis is a sexually transmitted infection causing significant global morbidity and mortality. To inform policymaking and economic evaluation studies for syphilis, we summarised utility and disability weights for health states associated ...
Patrick Miao, Fern Terris-Prestholt, Christopher K. Fairley, Joseph D. Tucker, Virginia Wiseman, Philippe Mayaud, Ying Zhang, Jane Rowley, Sami Gottlieb, Eline L. Korenromp, Caroline G. Watts, Jason J. Ong   +11 more
doaj   +1 more source

Resolving inconsistencies in utility measurement under risk: Tests of generalizations of expected utility [PDF]

This paper explores biases in the elicitation of utilities under risk and the contribution that generalizations of expected utility can make to the resolution of these biases.
Han Bleichrodt, Ildefonso Méndez-Martínez, José María Abellán-Perpiñan, JoséLuis Pinto   +3 more
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Evolution of social inequalities in health in Quebec? [PDF]

This paper, based on data from the National Population Health Surveys (NPHS) from 1994 to 2007, analyzes the evolution of social inequalities in health in Quebec since the mid-1990s using two health measures namely self-assessed health (SAH) and health ...
Batana, Yélé Maweki
core   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Testing the predective validity of the time trade-off and the Stardard Gamble [PDF]

This paper tests the consistency of health utility measurements with individual preferences. We compare three methods, the time trade-off, the standard gamble and a version of the standard gamble that corrects for the deviations from expected utility ...
Han Bleichrodt, Jose Luis Pinto-Prades, Jose María Abellán-Perpiñán   +2 more
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source