Results 151 to 160 of about 10,819,007 (349)
A new preference reversal in health utility measurement [PDF]
A central assumption in health utility measurement is that preferences are invariant to the elicitation method that is used. This assumptioin is challenged by preferences reversals.
Han Bleichrodt, Jose Luis Pinto-Prades
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Journal of Blood MedicineHarneet Kaur,1 Debjit Ghoshal,2 Inderpreet Singh Khurana2 1Takeda Pharmaceuticals International AG, Zurich, Switzerland; 2Lumanity, Gurugram, IndiaCorrespondence: Harneet Kaur, Takeda Pharmaceuticals International AG, Thurgauerstrasse 130, 8152 Glattpark
Kaur H, Ghoshal D, Khurana IS
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
USING CHOICE EXPERIMENTS TO ELICIT FARMERS PREFERENCES? FOR CROP AND HEALTH INSURANCE [PDF]
A random utility discrete choice experiments is used to determine farmers' preferences for health insurance, crop insurance, and a product that switches some portion of crop insurance subsidy to health insurance premium subsidy with access to large-pool ...
Gustafson, Cole R. +3 more
core +1 more source
INNOVATIONS in pharmacy, 2018 Faculty Discussant: A. Simon Pickard, PhDArticle 1: Real-World Cost-Effectiveness Analysis of Allogeneic Hematopoietic Stem Cells Transplantation vs. Hydroxyurea Therapy in Children with Sickle Cell DiseaseJifang Zhou, MD, MPH; Gregory S. Calip, PharmD, MPH, PhDArticle 2: Fondaparinux Sodium Compared with Low Molecular Weight Heparins for ...
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Measurement of SF-6D utility among patients with active tuberculosis [PDF]
Inspite of so much development in medical technology, Tuberculosis (TB) is still the problem for humans. Few studies, in Pakistan highlighted the factors that affect patients health related quality of life (HRQOL) with active TB. The aim of this study is
Aslam, Muhammad Amir +3 more
core +1 more source