Results 171 to 180 of about 10,819,007 (349)

Resolving inconsistencies in utility measurement under risk: Tests of generalizations of expected utility [PDF]

This paper explores biases in the elicitation of utilities under risk and the contribution that generalizations of expected utility can make to the resolution of these biases.
Han Bleichrodt, Ildefonso Méndez-Martínez, José María Abellán-Perpiñan, JoséLuis Pinto   +3 more
core  

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Subgroups of Patients with Distinct Health Utility Profiles after AKI. [PDF]

Kidney360, 2023
Kwong YD, Liu KD, Hsu CY, Cooper B, Palevsky PM, Kellum JA, Johansen KL, Miaskowski C.   +7 more
europepmc   +1 more source

Decision makers\u27 experience of participatory dynamic simulation modelling: Methods for public health policy [PDF]

, 2018
Background: Systems science methods such as dynamic simulation modelling are well suited to address questions about public health policy as they consider the complexity, context and dynamic nature of system-wide behaviours.
Atkinson, Jo-An, Freebairn, Louise, Kelly, Paul M, McDonnell, Geoff, Rychetnik, Lucie   +4 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Cataloging health state utility estimates for Duchenne muscular dystrophy and related conditions

Health and Quality of Life Outcomes
Background Duchenne muscular dystrophy (DMD) is a genetic disease resulting in progressive muscle weakness, loss of ambulation, and cardiorespiratory complications. Direct estimation of health-related quality of life for patients with DMD is challenging,
Lauren A. Do, Lauren E. Sedita, Alexa C. Klimchak, Rachel Salazar, David D. Kim   +4 more
doaj   +1 more source

Generic Health Utility Measures in Exercise Oncology: A Scoping Review and Future Directions. [PDF]

Curr Oncol, 2023
Parkinson JF, Ospina PA, Round J, McNeely ML, Jones CA.   +4 more
europepmc   +1 more source

Valuation of the Child Health Utility Index 9D (CHU9D) [PDF]

Objectives The aim of this study was to test the feasibility of estimating preference weights for all health states defined by the Child Health Utility 9D (CHU9D), a new generic measure of health related quality of life for children.
Stevens, K
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Impact of surgical-site infection on health utility values: a meta-analysis. [PDF]

Br J Surg, 2023
McFarland AM, Manoukian S, Mason H, Reilly JS.   +3 more
europepmc   +1 more source