Results 141 to 150 of about 2,949,264 (318)

Research Data Management In The Field Of Pediatric Healthcare [PDF]

This thesis investigates the current state of Research Data Management (RDM) in pediatric healthcare, highlighting the unique challenges and opportunities within this specialized field.
Abuhouran Dababneh, Saba S F
core  

Physicians’ attitudes and acceptance towards artificial intelligence in medical care: a qualitative study in Germany

Frontiers in Digital Health
BackgroundThe role of artificial intelligence (AI) in medicine is rapidly expanding, with the potential to transform physicians’ working practices across various areas of medical care.
Sarah Negash, Jana Gundlack, Charlotte Buch, Timo Apfelbacher, Jan Schildmann, Thomas Frese, Jan Christoph, Jan Christoph, Rafael Mikolajczyk   +8 more
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The impact of healthcare on global warming and human health: connecting the dots [PDF]

, 2017
The aim of this paper is to explore climate change and the impact that this is having on human health. The paper takes the reader through a brief history of climate change, making links between raising global temperatures and the environmental effects ...
Fernandez, A., Griggs, C., Callanan, M.
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An Integrative Systematic Review of Promoting Patient Safety Within Prehospital Emergency Medical Services by Paramedics: A Role Theory Perspective

Journal of Multidisciplinary Healthcare
Maria Strandås,1 M Flores Vizcaya-Moreno,2 Kari Ingstad,3 Jaana Sepp,4 Ljudmila Linnik,4 Mojtaba Vaismoradi1,5 1Faculty of Nursing and Health Sciences, Nord University, Bodø, Norway; 2Department of Nursing, Faculty of Health Sciences, University of ...
Strandås M, Vizcaya-Moreno MF, Ingstad K, Sepp J, Linnik L, Vaismoradi M   +5 more
doaj  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying healthcare actors involved in the adoption of information systems [PDF]

, 2007
The adoption of information systems in healthcare is no less significant than in any other commercial or caring organisation. The literature on IS adoption in healthcare, makes it clear that the actors involved in the adoption process are almost ...
M. TEMISTOCLEOUS, Irani, Z, Mantzana, V, Z. IRANI, Themistocleous, M, MORABITO, VINCENZO, V. MANTZANA, Morabito, V   +7 more
core  

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source