Results 61 to 70 of about 4,511,882 (288)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Hospital and Physician Capacity Update [PDF]

, 2009
Offers an alternative view of healthcare costs by examining trends in hospital capacity and healthcare labor across regions. Outlines how effective management of healthcare capacity would enable affordable quality care that meets patient needs and ...
David C. Goodman, Elliott S. Fisher, Kristen K. Bronner   +2 more
core  

Healthcare Access vs. Quality Healthcare: Rethinking Healthcare Risks

Public Health Reviews
ObjectivesThis narrative literature review examines the global burden of mortalities due to poor quality care compared to mortalities resulting from lack of access to healthcare, focusing on the period from 2015 to 2024.MethodsData was extracted from electronic databases such as PubMed, Google Scholar, Scopus, Ebscohost, and WHO. Relevant statistics on
openaire   +3 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Describing Barriers to Healthcare Access in the Homer Area, Alaska [PDF]

, 2016
Presented to the Faculty of the University of Alaska Anchorage in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCEData on healthcare access barriers are lacking for any location in the state of Alaska.
Zatz, Lisa M.
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Cybersecurity for Sustainable Internet of Things Implementation in Healthcare [PDF]

International Journal Bioautomation
The current systematic review aims to summarise and discuss the impact and implications of the Internet of Things (IoT) in the healthcare sector. An electronic search for articles using Google Scholar, PubMed, and Scopus was conducted from January 1 ...
Teodora Bakardjieva, Antonina Ivanova, Yanko Yankov, Zhivko Zhekov   +3 more
doaj   +1 more source

Healthcare professionals’ assumptions as barriers to LGBTI healthcare [PDF]

Culture, Health & Sexuality, 2019
Lesbian, gay, bisexual, trans and intersex (LGBTI) people experience significant healthcare inequalities and barriers to healthcare services. Contextualised within six Member States of the European Union (EU), this paper discusses efforts to identify and explore the nature of barriers to healthcare as part of Health4LGBTI, a 2-year pilot project funded
McGlynn, Nick, Browne, Kath, Sherriff, Nigel, Zeeman, Laetitia, Mirandola, Massimo, Gios, Lorenzo, Davis, Ruth, Donisi, Valeria, Farinella, Francesco, Rosińska, Magdalena, Niedźwiedzka-Stadnik, Marta, Pierson, Anne, Pinto, Nuno, Hugendubel, Katrin   +13 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Benefits realisation for healthcare [PDF]

, 2009
Following the emergent importance of benefits realisation applied to healthcare infrastructure and service development programs, HaCIRIC has undertaken a research initiative targeting the development of a robust and comprehensive Benefits Realisation ...
Kagioglou, M, Lima, JB, Sapountzis, S, Yates, KA   +3 more
core