Results 81 to 90 of about 4,511,882 (288)

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Global health concern on the rising dengue and chikungunya cases in the American regions: Countermeasures and preparedness

Health Science Reports
Background and Aim Severe morbidity and mortality due to seasonal infectious diseases are common global public health issues. Vector‐borne viral illnesses like dengue and chikungunya overload the healthcare systems leading to critical financial burden to
Ranjan K. Mohapatra, Priyadarshini Bhattacharjee, Dhruv N. Desai, Venkataramana Kandi, Ashish K. Sarangi, Snehasish Mishra, Ranjit Sah, Amani Ahmed AL. Ibrahim, Ali A. Rabaan, Kudrat E. Zahan   +9 more
doaj   +1 more source

Digital Twins for Cyber-Physical Healthcare Systems: Architecture, Requirements, Systematic Analysis, and Future Prospects

IEEE Access
Over the past few years, the demand for personalized and accurate healthcare solutions has significantly increased, aiming to enhance medical effectiveness.
M. S. Roopa, K. R. Venugopal
doaj   +1 more source

U-Care: Requirements Elicitation For Ambient Assisted Living [PDF]

, 2009
Western countries are facing similar trends in healthcare: population is aging, life expectations are growing, the number of healthcare professionals is decreasing, cost pressure on healthcare systems is increasing and urbanization is taking place.
Beijnum, B.J.F. van, Hermens, H.J., Klooster, J.W. van 't   +2 more
core   +2 more sources

APEL, APL or CPD? [PDF]

, 2010
Acquired prior experiential learning (APEL), acquired prior learning (APL) and/or continuous professional development (CPD) in the form of short courses or degree courses can ensure current and future employment.CPD is a requirement of regulatory and ...
Cox, C. L.
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Accessing Patient Records in Virtual Healthcare Organisations

, 2005
The ARTEMIS project is developing a semantic web service based P2P interoperability infrastructure for healthcare information systems that will allow healthcare providers to securely share patient records within virtual healthcare organisations ...
Boniface, M. J., Finlay, L., Leonard, T. A., McCorry, D., Surridge, M., Taylor, S. J.   +5 more
core  

Healthcare use for diarrhoea and dysentery in actual and hypothetical cases, Nha Trang, Viet Nam. [PDF]

, 2004
To better understand healthcare use for diarrhoea and dysentery in Nha Trang, Viet Nam, qualitative interviews with community residents and dysentery case studies were conducted. Findings were supplemented by a quantitative survey which asked respondents
Canh, Do Gia, Clemens, John D, Genberg, Becky L, Kaljee, Linda, Minh, Truong Tan, Thiem, Vu Dinh, Tho, Le Huu, Thoa, Le Thi Kim, Trach, Dang Duc, von Seidlein, Lorenz   +9 more
core